One hundred eighty-one dissected hands were examined to study the pattern of extensor tendons on the dorsum of the hand. Extensor digitorum often had multiple tendons for the middle and ring fingers. Its contribution to the little finger was usually by a bifurcating tendon common with that of the ring finger. The index finger always received a single tendon. Intertendinous connections between the various tendons of the extensor digitorum were variable but were most frequent between ring and middle fingers. Extensor indicis had one tendon in most of the specimens and it was always on the ulnar side of the extensor digitorum tendon. This remained true even when there were multiple tendons. Extensor digiti minimi had two tendons in most cases. It was always linked to extensor digitorum either by receiving one or part of its tendon or by an intertendinous connection. Two accessory muscles were seen, one was extensor indicis brevis replacing the proper muscle. The other, the extensor medii brevis, was distributed to the middle finger.

The pattern of distribution of cholinergic and adrenergic nerves in the uterus of albino rats and guinea pigs was examined histochemically. In the albino rat, the uterus was found well-innervated by both adrenergic and cholinergic nerves with a clear regional variation. Dense innervation was demonstrated at the tubal and cervical ends of the uterus and in the cervix. Cholinergic nerves supplying the glands were more numerous than the adrenergic nerves which were relatively few. In the guinea-pigs, the uterus was richly innervated by adrenergic nerves with a clear regional variation. No cholinesterase-positive nerves or nerve cells were demonstrated.

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Histological changes were studied in experimental animals following the intraperitoneal administration of high-dose cisplatin with or without high-dose methotrexate and citrovorum factor. There were pronounced renal toxicities with high-dose (10 mg/kg) cisplatin, particularly involving distal tubules with glomerular congestion. However, lower toxicities were noted with reduced dosage of cisplatin (5 mg/kg) and especially if given once as a single bolus injection instead of a 5-day regimen. Renal and hepatic toxicities were marked with concomitant methotrexate administration leading to hemorrhagic diathesis and shorter survival. However, toxicities were relatively reduced when cisplatin was given as a single bolus injection instead of a 5-day divided course. Such information may prove helpful in future planning of combination chemotherapy in patients with malignancies using these two agents.

The thoracic pedicle is generally cylindrical with various  indentations on its surface that may introduce an error in measurements, thus making the measurements unreliable. One hundred and eighty thoracic pedicle diameter measurements were carried out in five cadaveric human thoracic spine specimens, using a Vernier caliper. Coefficient of variation (CV) was used to evaluate the variation in measurements within and between  pedicles. Linear regression model was used to evaluate the  relationship between the variation in measurements and the average diameter of the bone per cadaver. The largest standard deviations in the five specimens were found at T2, T3, T6 and T12 levels. The least standard deviations were found at T1, T7, T9, T10 and T11. Four specimens demonstrated a negative linear relationship between the coefficient of variation and the average transverse diameter of the pedicle. This relationship was  significant (p<0.05) in two specimens. Vernier caliper measurements tend to be less reliable as the thoracic pedicle transverse diameter decreases. Caution is required when measuring the thoracic pedicle transverse diameter in the narrower mid-thoracic area of the spine with Vernier calipers.Keywords: reliability, thoracic pedicle morphometry

The fifth lumbar spinal nerve traverses a highly mobile transitional junction of the vertebral column. Evidence suggests that it is often implicated in the etiology of low-back pain, notably in entrapment syndromes. There appears to be a high incidence of unsuccessful attempts at surgical decompression in cases of suspected entrapment of the nerve, suggesting that perhaps the anatomical information on the topography of the nerve is incomplete. The present study examined the course and relations of the fifth lumbar spinal nerve by gross dissection of human cadaveric material. The results showed that the nerve and its subdivisions follow a complex, tortuous course as they cross the lumbosacral junction. The trunk and ventral and dorsal rami are all related to strong ligaments that are thought to be protective. The nearness of these nerves to ligaments in such an area of high mobility, however, predisposes them to impingement or entrapment in the event of joint or ligamentous pathology. It is suggested therefore that investigations of spondylogenic low-back pain should include a detailed evaluation of the status of all parts of the fifth lumbar spinal nerve as they traverse their individual osteoligamentous compartments.

In the present investigation partial degeneration of adrenergic and cholinergic nerves of the heart of guinea pigs following methotrexate treatment has been reported. No appreciable change was observed in the autonomic nerve fibres after 3 days of treatment. However, after prolonged treatment some nerve fibres showed signs of degeneration and a few adrenergic and cholinergic nerve fibres had disappeared.

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