Recent reports suggest an association between Chlamydia pneumoniae and Helicobacter pylori bacteria and atherosclerosis. We studied 51 patients (mean age, 68.3 years) who underwent abdominal aortic aneurysm surgery. For each patient we performed a microimmunofluorescence test for immunoglobulin G (IgG), IgA, and IgM antibodies to C. pneumoniae specific antigen (TW-183). Anti-H. pylori antibodies were determined by means of an EIA-G test. Each aortic aneurysm surgical specimen was sampled into multiple sections of 0.3 cm 2 each and frozen at ؊20؇C. Two samples of each aneurysm were used for a nested PCR with two sets of C. pneumoniae and two sets of H. pylori specific primers. Specimens were treated with a solution containing 20 mM Tris-HCl, Tween 20-Nonidet P-40 (0.5% [vol/vol] each), and 100 g of proteinase K per ml and incubated at 60؇C for 1 h and at 98؇C for 10 min. DNA was extracted twice with phenol-chloroform-isoamylic alcohol and precipitated with sodium acetate-ethanol by standard methods. Forty-one patients were seropositive for C. pneumoniae with past-infection patterns in 32 patients (16 < IgG < 512; 32 < IgA < 256) and high antibody titers in 9 patients (IgG > 512). In 26 of 51 patients, C. pneumoniae DNA was detected in aortic aneurysm plaque specimens. Of these patients, 23 had a serologic past-infection pattern, 2 had an acute reinfection pattern, and 1 was seronegative. Forty-seven of 51 patients were seropositive for H. pylori. In all cases PCR showed no evidence of H. pylori presence in plaque specimens. This study provides data on a possible C. pneumoniae involvement in the pathogenesis of aortic aneurysm and additional evidence for an association between this agent and atherosclerosis. Conversely, notwithstanding a high H. pylori seroprevalence observed, our results tend to rule out the possibility of a direct involvement of H. pylori in atherosclerosis.
No abstract
Nel Tesoro del Duomo di Monza si conservano tre celebri dittici eburnei relativi alla dotazione di suppellettili liturgiche di Berengario del Friuli (inizi X secolo): il dittico di Stilicone e quello del Poeta e della Musa, entrambi tardo antichi; il dittico di re Davide e san Gregorio Magno, di datazione e lettura più controverse (VI secolo ed età carolingia). Primo editore dei pezzi è Anton Francesco Gori nel secondo volume del Thesaurus veterum diptychorum consularium et ecclesiasticorum (1759), corredato di tre tavole di Andrea Scacciati. Pur non avendo mai visionato i manufatti, l’erudito fiorentino dedica ad essi un’ampia disamina critica basandosi essenzialmente sugli acquerelli del pittore Girolamo Ferroni, reclutato dal marchese milanese e prezioso intermediario Alessandro Teodoro Trivulzio. Nel 1794 il padre della storiografia monzese, il canonico Anton Francesco Frisi, risolve di rieditare i dittici in apertura del terzo tomo delle sue Memorie storiche di Monza e sua corte. Consigliato da quel don Carlo Trivulzio erudito e proprietario di un ricco nucleo di avori antichi, supportato dalle modeste incisioni di Giulio Cesare Bianchi, offre una rilettura che puntualizza ed emenda in parte quanto scritto dal Gori, condita da una vena polemica contro «chi non ha esaminati personalmente i Monumenti, sui quali ragiona». Sullo sfondo del contesto culturale dell’epoca e delle personalità che vi presero parte, con l’ausilio della documentazione divisa tra la Veneranda Biblioteca Ambrosiana di Milano, l’Archivio della Fondazione Trivulzio e la Biblioteca Marucelliana di Firenze, il contributo intende proporre una ricostruzione degli avvenimenti con attenzione al rapporto tra originale (i dittici monzesi) e copia (disegni e incisioni che ne scaturirono).
La maladie grave de l’enfant, comme le cancer, génère un stress intense chez les parents, pouvant entraîner des troubles anxieux et dépressifs. Ce chapitre propose de questionner la problématique du stress maternel dans le cas spécifique des tumeurs cérébrales pédiatriques (TCP) à partir d’une recherche française réalisée en 2019, grâce à une validation française du « Pediatric Inventory for Parents » (PIP). Les résultats ayant notamment mis en évidence les inquiétudes maternelles pour le devenir scolaire de l’enfant, l’expérience scolaire de celui-ci, et plus généralement la re-scolarisation en cas de TCP seront investiguées au travers d’une synthèse d’articles sur les dispositifs et les parties prenantes de la réinsertion scolaire. La synthèse met en exergue l’importance de facteurs essentiels à la re-scolarisation de ces enfants cérébrolésés, comme l’implication des enseignants face au handicap visible et la collaboration entre les parents et les enseignants.
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