Correspondence

Blasi, Francesco; Ranzi, M. L.; Erba, M; Tarsia, Paolo; Raccanelli, Rita; Fagetti, L.; Allegra, L.

doi:10.1016/0021-9150(96)05921-7

Cited by 15 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although some studies found H. pylori in atherosclerotic plaques,[16172021] some other researchers found no evidence of H. pylori in the endarterectomy plaques of patients who were seropositive for H. pylori . [33343536373839] Thus, the issue of an association between H. pylori and atherosclerosis remains controversial. [40]…”

Section: Discussionmentioning

confidence: 99%

“…In all cases PCR showed no evidence of H. pylori presence in atherosclerotic plaque specimensalthough 92.1% of patients were seropositive for H. pylori . [3334] Kaklikkaya et al ., reported 21 patients undergoing surgery for aortoiliac occlusive disease, searching for H. pylori in aorta-iliac atherectomy specimens by PCR. They did not find H. pylori in any of specimens.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

No detection of Helicobacter pylori in atherosclerotic plaques in end stage renal disease patients undergoing kidney transplantation

et al. 2013

View full text Add to dashboard Cite

Chronic infection known to be a predisposing factor for the development of atherosclerosis. Several studies have found a possible role of Helicobacter pylori in the pathogenesis of atherosclerosis. The aim of this study was to investigate the presence of H. pylori in atherosclerotic plaques in iliac arteries in 25 end stage renal disease (ESRD) patients undergoing kidney transplantation. Esophagogastroduodenoscopy was performed in all patients before transplantation. Biopsy specimens obtained from gastric antrum were sent for pathologic evaluation. Gastric H. pylori infection was confirmed by microscopic assessment and rapid urease test. Arterial specimens were obtained from iliac arteries during kidney transplantation. Presence of H. pylori DNA in atherosclerotic plaques and healthy vessel samples was evaluated by the polymerase chain reaction (PCR). The mean age of patients was 44.1 ± 22.6 years. Risk factors in patients with atherosclerosis were hypertension (68%), diabetes mellitus (20%), hyperlipidemia (20%), positive family history (16%). Atherosclerotic plaques were found in 21 (84%) patients. PCR analysis did not detect H. pylori in any case. There was a significant relationship of atherosclerosis with hypertension (P = 0.006) but not with diabetes mellitus and hyperlipidemia (P = 0.5). There was no significant relationship between atherosclerosis and gastric H. pylori infection (P = 0.6). This study revealed no association between the presence of H. pylori as a pathogen of vessel walls and atherosclerosis in ESRD.

show abstract