An Escherichia coli gene located in the enterobactin gene cluster between fepB and entE was sequenced. The nucleotide sequence showed a 53% similarity to those of the related genes pabB and trpE; at the amino acid level, the homology was approximately 20%. The pabB and trpE genes encode enzymes that use chorismate as a substrate suggesting that the gene sequenced here is entC,. whose cognate protein is isochorismate synthase. A binding site for the iron regulatory protein Fur was found upstream from entC and only 9 bp separated entC from entE, indicating that entCE are cotranscribed.
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