Articles you may be interested inBrandaris 128 ultra-high-speed imaging facility: 10 years of operation, updates, and enhanced features Rev. Sci. Instrum. 83, 103706 (2012); 10.1063/1.4758783 High speed single charge coupled device Cranz-Schardin camera Rev. Sci. Instrum. 78, 035111 (2007); 10.1063/1.2714771Million frames per second infrared imaging system Rev.A high-speed camera that combines a customized rotating mirror camera frame with charge coupled device ͑CCD͒ image detectors and is practically fully operated by computer control was constructed. High sensitivity CCDs are used so that image intensifiers, which would degrade image quality, are not necessary. Customized electronics and instruments were used to improve the flexibility and control precisely the image acquisition process. A full sequence of 128 consecutive image frames with 500ϫ292 pixels each can be acquired at a maximum frame rate of 25 million frames/s. Full sequences can be repeated every 20 ms, and six full sequences can be stored on the in-camera memory buffer. A high-speed communication link to a computer allows each full sequence of about 20 Mbytes to be stored on a hard disk in less than 1 s. The sensitivity of the camera has an equivalent International Standards Organization number of 2500. Resolution was measured to be 36 lp/mm on the detector plane of the camera, while under a microscope a bar pattern of 400 nm spacing line pairs could be resolved. Some high-speed events recorded with this camera, dubbed Brandaris 128, are presented.

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These results indicate the feasibility of contrast harmonic intravascular ultrasound as a new technique for vasa vasorum imaging.

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A number of recent studies have indicated the potential of ultrasound contrast agent imaging at high ultrasound frequencies. However, the acoustic properties of microbubbles at frequencies above 10 MHz remain poorly understood at present. In this study we characterize the high frequency attenuation properties of (1) BR14, (2) BR14 that has been mechanically filtered (1 and 2 lm pore sizes) to exclude larger bubbles, and (3) the micron to submicron agent BG2423. A narrowband pulse-echo substitution method is employed with a series of four transducers covering the frequency range from 2 to 50 MHz. For BR14, attenuation decreases rapidly from 2 to 10 MHz and then more gradually from 10 to 50 MHz. For 2 lm filtration, the attenuation peaks between 10 and 15 MHz. For 1 lm filtration, attenuation continues to rise until 50 MHz. The agent BG2423 exhibits a diffuse attenuation peak in the range of 15-25 MHz and remains high until 50 MHz. These results demonstrate a strong influence of bubble size on high frequency attenuation curves, with bubble diameters of 1-2 lm and below having more pronounced acoustic activity at frequencies above 10 MHz.

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