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Objective: to evaluate the potential clinicopathological involvement of macrophage migration inhibitory factor (MIF) in systemic lupus erythematosus (SLE), and its relationship with lupus nephritis (LN) through measuring serum and urinary MIF levels. Methods: A crosssectional case-control study was carried out on 30 SLE female patients and 30 healthy age-matched females as a control group. SLE activity was assessed by the Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI-2k) and renal activity was evaluated with the renal-SLEDAI (rSLEDAI-2k). SLE damage was evaluated by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage index. Serum MIF (sMIF), urinary MIF (uMIF) levels were assayed and uMIF/creatinine ratio was estimated in all studied subjects. Results: SLE patients had significantly higher levels of sMIF, uMIF and uMIF/ creatinine ratio than the control group (p <0.001 for each).They were also significantly higher in SLE patients with lupus nephritis compared with those without lupus nephritis (p <0.001 for each) and in patients with active nephritis compared with inactive cases (p= 0.007, 0.001, 0.018, respectively). There were significant increase in sMIF, uMIF levels and uMIF/creatinine ratio in association with disease activity assessed by SLEDAI (p =0.005, 0.026, 0.049, respectively). Through regression analysis revealed that sMIF, uMIF, uMIF/creatinine ratio were found to be independent predictors for lupus nephritis development. Conclusion:This study showed that MIF is related to renal disease activity in SLE. Further prospective studies are required to verify whether MIF has a prognostic value in predicting clinical outcomes in SLE patients with different therapeutic regimens.

Toxemia (PE) is characterized as new-beginning hypertension creating following 20 weeks' incubation with at least one of the accompanying: proteinuria, maternal organ brokenness (counting renal, hepatic, hematological, neurological complica¬tions), as well as fetal development restriction.Aim and destinations: The point of this examination was to think about serum levels of IL-27 between preeclamptic ladies with obviously solid pregnant and non-pregnant women.Methods: One hundred and twenty females went to Gynecology and Obstetrics office and outpatient facility, Benha University Hospitals were partitioned into three gatherings; understanding gathering: included 40 pregnant ladies with PE, typical pregnant gathering: included 40 females with ordinary pregnancy and non-pregnant gathering: included 40 evidently sound non-pregnant female.Results: Serum IL-27 was essentially higher in toxemia cases more than the sound pregnant and non-pregnant controls (P < 0.001). End: Serum IL-27 might be helpful in determination of pregnant ladies compilicated by toxemia.

No abstract

Psoriasis is a constant fiery dermatological infection that is regularly connected with foundational comorbidities. The psoriatic skin shows penetration and collection of a few fiery and insusceptible cells and broad arrival of proinflammatory cytokines and chemokines. This brought about hyperproliferation of keratinocytes with halfway loss of separation. Cystatin C (Cys C) is a little sub-atomic weight particle that is communicated in the majority of the natural tissues. Cys C is equipped for a few physiological and obsessive activities. The harmony between these impacts is sensitive and relies upon focus and term of delivery. Point of the work: The introduced examination expected to assess the serum level of Cys C in patients with 50 patients with summed up plaque psoriasis and 30 sound people as a control were remembered for this investigation. Results: Serum Cys C is altogether raised in psoriatic patients than control with a positive huge connection with psoriasis seriousness.