Background
Anogenital warts (
AGW
) can cause economic burden on healthcare systems and are associated with emotional, psychological and physical issues.
Objective
To provide guidance to physicians on the diagnosis and management of
AGW
.
Methods
Fourteen global experts on
AGW
developed guidance on the diagnosis and management of
AGW
in an effort to unify international recommendations. Guidance was developed based on published international and national
AGW
guidelines and an evaluation of relevant literature published up to August 2016. Authors provided expert opinion based on their clinical experiences.
Results
A checklist for a patient's initial consultation is provided to help physicians when diagnosing
AGW
to get the relevant information from the patient in order to manage and treat the
AGW
effectively. A number of frequently asked questions are also provided to aid physicians when communicating with patients about
AGW
. Treatment of
AGW
should be individualized and selected based on the number, size, morphology, location, and keratinization of warts, and whether they are new or recurrent. Different techniques can be used to treat
AGW
including ablation, immunotherapy and other topical therapies. Combinations of these techniques are thought to be more effective at reducing
AGW
recurrence than monotherapy. A simplified algorithm was created suggesting patients with 1–5 warts should be treated with ablation followed by immunotherapy. Patients with >5 warts should use immunotherapy for 2 months followed by ablation and a second 2‐month course of immunotherapy. Guidance for daily practice situations and the subsequent action that can be taken, as well as an algorithm for treatment of large warts, were also created.
Conclusion
The guidance provided will help physicians with the diagnosis and management of
AGW
in order to improve the health and quality of life of patients with
AGW
.
There is an association between cancer-associated myositis and interstitial lung diseases and their hallmark autoantibodies in our cohort. In addition, the combined determination of myositis-specific autoantibodies and SSA autoantibodies may help to accurately discriminate SCLE from CADM.
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