Background Adult granulosa cell tumors (AGCTs) are the most common sex cord-stromal tumors. Unlike epithelial ovarian tumors, they occur in young women and are usually detected at an early stage. The aim of this study was to report the clinical and pathological characteristics of AGCT patients and to identify the prognostic factors. Methods All cases of AGCTs, treated at Salah Azaïz Institute between 1995 and 2010, were retrospectively included. Kaplan-Meier's statistical method was used to assess the relapse-free survival and the overall survival. Results The final cohort included 31 patients with AGCT. The mean age was 53 years (35–73 years). Patients mainly presented with abdominal mass and/or pain (61%, n = 19). Mean tumor size was 20 cm. The majority of patients had a stage I disease (61%,  n = 19). Two among 3 patients with stage IV disease had liver metastasis. Mitotic index was low in 45% of cases (n = 14). Surgical treatment was optimal in almost all cases (90%, n = 28). The median follow-up time was 14 years (1–184 months). Ten patients relapsed (32%) with a median RFS of 8.4 years (6.8–9.9 years). Mean overall survival was 13 years (11–15 years). Stage I disease and low-to-intermediate mitotic index were associated with a better prognosis in univariate analysis (resp., p = 0.05 and p = 0.02) but were not independent prognostic factors. Conclusion GCTs have a long natural history with common late relapses. Hence, long active follow-up is recommended. In Tunisian patients, hepatic metastases were more frequent than occidental series. The prognosis remains good and initial staging at diagnosis is an important prognostic factor.

Prognostic impact of tumor location should be considered as a stratification factor in the future clinical trials.

Objective:Implantable port thrombosis (IPT) in cancer patients is a relatively rare but severe complication. Several factors are reportedly associated with the occurrence of thrombosis. We aimed to describe the prevalence and the anatomoclinical features of IPT observed in cancer patients who were treated in a medical oncology department in Tunisia.Methods:A total of 600 cancer patients who had port implantation from January 2013 to December 2015 were retrospectively identified. Cases with symptomatic/incidental IPT (radiologically confirmed) were further identified. Epidemiological and anatomoclinical features were collected from patient records and the department database.Results: We observed that 33 of the 600 patients had IPT; thus, the prevalence was 5.5%. The median age was 57 years, and the gender ratio was 0.43. Overweight or obesity was observed in 73% of the patients. IPT occurred mainly in patients with breast (36.4%) and colorectal (33.3%) cancers, which were mostly nonmetastatic (79%). At least one identified classical thromboembolic risk factor was found in 13 patients (smoking in 9, tamoxifen in 2). IPT was symptomatic in 93% of the cases, occurring within an average time of 56 days. Implantable ports were removed because of infection in 2 cases and nonfunctionality in 3 cases. IPT treatment was based on low-molecular-weight heparins (94%) and antivitamin K (6%) for an average of 130 days. Four patients had post-therapy complications: one thrombosis recurrence and three infections.Conclusions:IPT cases in the 600 patients were observed to occur in obese nonmetastatic cancer patients within the first 3 months after IP implantation.

Aim: We aimed to identify a cutoff value of tumor size (TuS) correlated to prognosis of stage II and III colorectal cancer and to evaluate the prognostic significance. Patients & methods: We retrospectively analyzed 257 patients treated for stage II–III colorectal cancer between 2003 and 2014. We used receiver-operating characteristic to evaluate TuS performance accuracy to predict survival. We identified a cutoff value. We used the Kaplan–Meier method and Cox regression analysis to study survival and prognostic factors. Results: Area under the receiver-operating characteristic curve of TuS was 0.62 ± 0.048. A size of 4 cm was identified as a predictor of survival with a sensitivity of 88.2% and a specificity of 59.2%. We observed 98 patients with TuS ≤4 cm and 159 patients with TuS greater than 4 cm. Patients with TuS greater than 4 cm were more likely to have a cancer located in the colon (81.1 vs 70.4%, p = 0.002) and commonly pT4 (44 vs 22.4%, p = 0.0001). There was no difference in terms of gender, insufficient removed lymph nodes number, number of positive lymph nodes, stage and oxaliplatin administration between both groups. 5-year survival rate of patients with TuS ≥4 cm and TuS less than 4 cm was 76 and 84%, respectively (p = 0.008). Age ≥65 years, stage III, venous invasion and pN+ greater than 3 were significant bad prognostic factors in patients with TuS ≥4 cm in univariate analysis. Stage III was the only independent prognostic factor in multivariate analysis. Administration of chemotherapy was the only factor with significant impact on survival in univariate and multivariate analyses in patients with TuS less than 4 cm. Conclusion: TuS had not only an impact on survival but also interfered with other prognostic factors.