Tumor location impact in stage II and III colon cancer: epidemiological and outcome evaluation

Mejri, Nesrine; Dridi, M.; Benna, Houda El; Labidi, Soumaya; Daoud, Nouha; Boussen, Hamouda

doi:10.21037/jgo.2017.12.02

Cited by 15 publications

(15 citation statements)

References 20 publications

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“…Next, we found a higher age in women compared to men (74 vs. 71 years, p = 0.001). Of CCs, 59.3 % were right-sided with a slightly higher incidence in women [32]. The PETACC-8 study reported a percentage of 38.9 % and the NO147 trial 50 % of right-sided cancers [21].…”

Section: Clinical Parametersmentioning

confidence: 96%

High microsatellite instability (MSI-H) is associated with distinct clinical and molecular characteristics and an improved survival in early Colon cancer (CC); real world data from the AIO molecular registry Colopredict Plus

et al. 2020

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Colorectal cancer is one of the leading malignancies and still accounts for almost 25 000 deaths in Germany each year. Although there is accumulating data on the molecular basis, treatment and clinical outcome of patients within clinical trials evidence from the real-world setting is mostly lacking. We started the molecular registry trial Colopredict Plus in 2013 to collect clinical and molecular data from a real-world cohort of patients with early colon cancer stage II and III in 70 German colon cancer centers focusing on the prognostic impact of high microsatellite instability. In this interim report, we characterize a clinical cohort of 2615 patients, of whom 1787 tissue probes were analyzed. Microsatellite status was assessed using immunhistochemistry and fragment length analysis, with a concordance of 91.4 %. These established histopathological methods are sensitive and cost-effective. The median age was 72 years, significantly higher compared to clinical trial populations, with a median Charlson Comorbidity Index of 3. The stage-dependent incidence of microsatellite instability was 23.7 % and was associated with female gender, BRAF-mutation, UICC stage II and localization in the right colon. Survival calculated in disease free, relapse free and overall survival significantly differed between MSI-H and MSS, in favor of MSI-H patients. Multivariate age-adjusted analyses of relapse-free survival, disease-free survival, and overall survival highlighted microsatellite instability as a robust and positive prognostic marker for early colon cancer independent of age.

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Section: Clinical Parametersmentioning

confidence: 96%

High microsatellite instability (MSI-H) is associated with distinct clinical and molecular characteristics and an improved survival in early Colon cancer (CC); real world data from the AIO molecular registry Colopredict Plus

et al. 2020

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“…Colon cancer ranks third among the gastrointestinal cancers, and its morbidity and mortality rates in men are higher than those in women (3). The 5years survival rate of colon cancer after radical operation is about 60-70%, and the main reasons leading to the failure of surgical treatment are post-operative recurrence and metastasis (4,5). Therefore, the discovery of valuable molecular markers is important for the early prediction and treatment of colon cancer recurrence.…”

Section: Introductionmentioning

confidence: 99%

A 6 lncRNA-Based Risk Score System for Predicting the Recurrence of Colon Adenocarcinoma Patients

et al. 2020

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Colon adenocarcinoma (COAD) is a common type of colon cancer, and post-operative recurrence and metastasis may occur in COAD patients. This study is designed to build a risk score system for COAD patients. The Cancer Genome Atlas (TCGA) dataset of COAD (the training set) was downloaded, and GSE17538 and GSE39582 (the validation sets) from Gene Expression Omnibus database were obtained. The differentially expressed RNAs (DERs) were analyzed by limma package. Using survival package, the independent prognosis-associated long non-coding RNAs (lncRNAs) were selected for constructing risk score system. After the independent clinical prognostic factors were screened out using survival package, a nomogram survival model was constructed using rms package. Furthermore, competitive endogenous RNA (ceRNA) regulatory network and enrichment analyses separately were performed using Cytoscape software and DAVID tool. Totally 404 DERs between recurrence and non-recurrence groups were identified. Based on the six independent prognosis-associated lncRNAs (including H19, KCNJ2-AS1, LINC00899, LINC01503, PRKAG2-AS1, and SRRM2-AS1), the risk score system was constructed. After the independent clinical prognostic factors (Pathologic M, pathologic T, and RS model status) were identified, the nomogram survival model was built. In the ceRNA regulatory network, there were three lncRNAs, four miRNAs, and 77 mRNAs. Additionally, PPAR signaling pathway and hedgehog signaling pathway were enriched for the mRNAs in the ceRNA regulatory network. The risk score system and the nomogram survival model might be used for predicting COAD recurrence. Besides, PPAR signaling pathway and hedgehog signaling pathway might affect the recurrence of COAD patients.

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“…also reported the prognostic impact of tumour location for stage II/III CC. Two hundred and three patients with stage II/III CC were analysed, and it was found that 5‐year OS was significantly worse in RCC than in LCC (65% versus 82%, HR 2.07; 95% CI 1.05–4.09; P = 0.03) 29 . A systemic review and meta‐analysis of prognostic survival associated with tumour localization was reported in Italy.…”

Section: Discussionmentioning

confidence: 99%

Prognostic impact of tumour sidedness in patients with stage II colon cancer: a single‐centre retrospective study

Iguchi

Mushiake

Fukushima

et al. 2021

ANZ Journal of Surgery

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Background The search for high‐risk factors in stage II colon cancer (CC) is ongoing and several high‐risk factors for stage II CC have been identified; however, the effects of tumour sidedness on prognosis are not clear. This study aims to determine whether tumour sidedness could be identified as another high‐risk factor for stage II CC. Methods We retrospectively analysed 189 patients with stage II CC and compared clinicopathological findings and long‐term outcomes between the patients with right colonic cancer (RCC) and with left colonic cancer (LCC). Prognostic factors for survival were determined using univariate and Cox proportional regression analyses. Results A total of 72 patients were diagnosed with RCC and 117 patients were diagnosed with LCC. Patients with RCC were significantly older (P < 0.001), and the number of harvested lymph nodes was greater in the RCC group (RCC: 25 versus LCC: 19; P = 0.003). The overall survival (OS) was worse in the RCC group than the OS in the LCC group (5‐year survival rate – RCC: 81.3% versus LCC: 90.4%; P = 0.025). Cox proportional regression analysis showed that tumour sidedness was an independent prognostic factor for both OS (hazard ratio (HR) 3.78, 95% confidence interval (CI) 1.61–8.85, P = 0.022) and DFS (HR 2.58, 95% CI 1.33–4.99, P = 0.005). Conclusion Patients with RCC have more negative prognostic factors and worse long‐term outcomes than those with LCC in stage II CC. Tumour sidedness is a high‐risk factor in stage II CC patients.

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Tumor location impact in stage II and III colon cancer: epidemiological and outcome evaluation

Abstract: Prognostic impact of tumor location should be considered as a stratification factor in the future clinical trials.

Cited by 15 publications

References 20 publications

High microsatellite instability (MSI-H) is associated with distinct clinical and molecular characteristics and an improved survival in early Colon cancer (CC); real world data from the AIO molecular registry Colopredict Plus

High microsatellite instability (MSI-H) is associated with distinct clinical and molecular characteristics and an improved survival in early Colon cancer (CC); real world data from the AIO molecular registry Colopredict Plus

A 6 lncRNA-Based Risk Score System for Predicting the Recurrence of Colon Adenocarcinoma Patients

Prognostic impact of tumour sidedness in patients with stage II colon cancer: a single‐centre retrospective study

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