This study confirmed that early values of clot amplitudes measured as soon as five, 10 or 15 min after clotting time could be used to predict maximum clot firmness in all ROTEM® tests.
ischaemic and bleeding events, and to calculate the confidence limits of these event rates, as we have done. 1 Now, with 44 patients and still no ischaemic events, our 97.5% upper confidence level is 8.04%, which is far below the event rates published by the Cleveland and Dutch investigators. 11 12 This prospective observational approach makes sense only if the participating hospitals agree to enrol consecutive patients with the study enrolment characteristics. Several other hospitals in Italy are now using our protocol, and a formal enlarged study is being submitted to our Ethical Committee, in order to have a more solid estimate of the performance of this treatment strategy. Whether this approach is solid enough to generate recommendations depends on the Guideline writing committees: based on our growing experience in treating these patients, bridge therapy using a short-acting antiplatelet agent is effective.
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