2015
DOI: 10.1093/bja/aev369
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Abstract: This study confirmed that early values of clot amplitudes measured as soon as five, 10 or 15 min after clotting time could be used to predict maximum clot firmness in all ROTEM® tests.

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Cited by 31 publications
(13 citation statements)
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“…First, this is a descriptive study with a surrogate (i.e., without a clinical) endpoint. However, as this surrogate endpoint has been correlated with relevant clinical endpoints in the past [64][65][66][67][68] and recently [69][70][71], it should allow generation of solid hypotheses to lay basis for further clinical studies. Also, this is a single center study, and the results may therefore be influenced by local specifics.…”
Section: Discussionmentioning
confidence: 99%
“…First, this is a descriptive study with a surrogate (i.e., without a clinical) endpoint. However, as this surrogate endpoint has been correlated with relevant clinical endpoints in the past [64][65][66][67][68] and recently [69][70][71], it should allow generation of solid hypotheses to lay basis for further clinical studies. Also, this is a single center study, and the results may therefore be influenced by local specifics.…”
Section: Discussionmentioning
confidence: 99%
“…Here, early amplitudes of clot firmness at 5 and 10 min after the time to initiate clotting (coagulation time, CT), e.g., amplitude of clot firmness 5 min after CT (A5; actually not yet available in the US) and amplitude of clot firmness 10 min after CT (A10; early clot firmness parameter also available in the US), correlate very well with maximum clot firmness (MCF), plasma fibrinogen concentration, and platelet count and are essential for a short turnaround time of ROTEM analysis ( Table 1 and Fig. 2) [21][22][23][24][25][26]. POC ROTEM testing does not only enable a shorter turnaround time compared to SLCTs, but these assays (such as FIBTEM) are also superior to SLCTs (such as plasma fibrinogen concentration) to predict bleeding and transfusion in several clinical settings [27][28][29][30][31].…”
Section: Introductionmentioning
confidence: 99%
“…A recent study suggested that early values of clot amplitudes could be used to predict maximum clot firmness. 75 Transfusion algorithms now make use of viscoelastic assays, and published guidelines support their use. 76 In children undergoing cardiac operations, viscoelastic tests can assess coagulopathy and guide the administration of blood products.…”
Section: Avoiding Bleeding: Surgical Technique and Topical Hemostasismentioning
confidence: 99%