BackgroundLipid accumulation product (LAP), a simple and low-cost tool, is a novel
biomarker of central lipid accumulation and represents a potential surrogate
marker for atherogenic lipoprotein profile. However, its association with
lipoprotein subfractions has not been described in the literature.ObjectiveTo determine whether LAP index could be used as a marker of low- and
high-density lipoprotein (LDL and HDL) size in Brazilian individuals.MethodsThis cross-sectional study included patients (n = 351) of both sexes and age
between 30-74 years. Clinical and sociodemographic data and family history
of diseases were evaluated. Lipoprotein size, and levels of total
cholesterol (TC), lipoproteins, apolipoprotein AI and B (APO AI/APO B),
glucose, insulin, insulin resistance index (HOMA-IR) and non-esterified
fatty acids (NEFA) were assessed in blood samples. LAP was calculated by the
formulas [(waist circumference[cm]-58)
× (triglycerides[mmol/L]) for women and
(waist circumference [cm]-65) ×
(triglycerides [mmol/L]) for men]. The
association between LAP and metabolic parameters were tested by linear trend
(general linear model, GLM test) before and after multiple adjustments for
potential confounders (sex, age, smoking, statin, fibrate, and hypoglycemic
drugs) at significant level p < 0.05.ResultsLAP was positively associated with TC, APO B, NEFA, glucose, insulin and
HOMA-IR values, and negatively associated with HDL-C. Higher central lipid
accumulation was corelated with higher percentage of intermediate HDL and of
small LDL and HDL and less amount of large HDL. LDL size was also reduced in
greater LAP index values. The negative impact of LAP was maintained after
adjustment for multiple variables.ConclusionLAP was robustly associated with atherogenic profile of lipoprotein
subfractions, independently of multiple confounders.
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