The Escherichia coli system is the system of choice for recombinant protein production because it is possible to obtain a high protein yield in inexpensive media. The accumulation of protein in an insoluble form in inclusion bodies remains a major disadvantage. Use of the Pseudomonas aeruginosa type III secretion system can avoid this problem, allowing the production of soluble secreted proteins.
Synthesis and Bovine β 3 -Adrenergic Agonistic Activities of a Novel Series of Aryloxypropanolamines.-23 Compounds of type (III), (VIII), (XVI), and (XX) are prepared and tested for their β 3 -adrenergic agonistic activities. (III) shows the best ratio between potency and affinity against β 3 -adrenoceptors. -(EL HADRI, A.; NICOLLE, E.; GUILLAUME, M. C.; LECLERC, G.; PIETRI-ROUXEL, F.; STROSBERG, A. D.; ARCHIMBAULT, PH.; Pharmazie 56 (2001) 7, 517-522; Dep. Pharmacochim. Mol./Glucides, CNRS, Univ. Joseph Fourier, F-38243 Meylan, Fr.; EN)
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