ChemInform Abstract: Synthesis and Bovine β₃‐Adrenergic Agonistic Activities of a Novel Series of Aryloxypropanolamines.

Abstract

Synthesis and Bovine β 3 -Adrenergic Agonistic Activities of a Novel Series of Aryloxypropanolamines.-23 Compounds of type (III), (VIII), (XVI), and (XX) are prepared and tested for their β 3 -adrenergic agonistic activities. (III) shows the best ratio between potency and affinity against β 3 -adrenoceptors. -(EL HADRI, A.; NICOLLE, E.; GUILLAUME, M. C.; LECLERC, G.; PIETRI-ROUXEL, F.; STROSBERG, A. D.; ARCHIMBAULT, PH.; Pharmazie 56 (2001) 7, 517-522; Dep. Pharmacochim. Mol./Glucides, CNRS, Univ. Joseph Fourier, F-38243 Meylan, Fr.; EN)

Design, Synthesis and In Vivo Cardiovascular Evaluation of Some Novel Aryloxy Propanol Amino Acid Derivatives

“…El Hedri et al, have displayed that introducing the bulky amines to propanol chain can remarkably enhance the selectivity of interaction with β‐adrenoceptores. Also, it was demonstrate that considering either mono or dicarboxyl groups on an alkylamine moiety can improve the selectivity, as well [16] . Various methods for the synthesis of aryloxypropanol amines and their derivatives were investigated [17] .…”