We have presented 7 patients in whom metastatic carcinoma regressed by chemotherapy alone. They are well without evidence of disease for 5 to 10 years. The patients include 4 embryonal carcinoma of the testis, 1 uterine chorioepithelioma, 1 prostatic sarcoma, and 1 trabeculo‐follicular epithelioma of the thyroid. They received 1 or more courses of chemotherapy (trenimon or nitromin alone, or triple association actinomycin D, methotrexate, and cytoxan). We cannot explain why these are apparently cured and why others, treated with the same drugs, had no regression at all. No immunological studies were done.
Chemotherapy appears to be of help in treating dysembryoplastic testicular tumors. It seems better to treat first by surgery (lymphadenectomy) if possible, then (a) if no nodes are involved or only one has been discovered by microscope examination, with chemotherapy for one year; or (b) if two or more nodes are involved, with irradiation of the nodes and chemotherapy. Even if lymphadenectomy is not possible, one course of chemotherapy followed by cobalt and more chemotherapy can bring results in some cases.
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