Efficacy of “8 drugs in 1 day” regimen in the treatment of poor risk childhood brain tumors

Efficacy of ?8-drugs-in-one-day? combination in treatment of recurrent GBM patients

“…If we assume that there is a small response (10%) for each cytotoxic agent used in this regimen and that the probability of response of each drug is independent of any other drug or of interactions between drugs, theoretically the final response of this regimen will be significantly increased. Actually, Pendergrass reported some encouraging results: 15.5% of cases with complete regression of the tumor mass, and 50% with partial tumor regression, other interesting results were referred by Olive (1984). In our study the results are less promising, probably because all our patients were recurrent GBM previously treated with radiotherapy.…”

A child with esthesioneuroblastoma with metastases to the spinal cord and the bone marrow

“…It can be speculated that not even a bone marrow transplantation would have cured the girl. Because chemotherapeutic agents do not cross the blood-brain barrier well, and there was clinical evidence of a residual tumor in the central nervous system, the "eight drugs in 1 day" regimen was tried because this has had promising results when used against brain tumors [7].…”

“…In September, there was still a heavy infiltrate of neuroblastoma-like cells in the bone marrow and the cerebrospinal fluid. Allogenous bone marrow transplantation was considered, but no suitable donor could be found, and chemotherapy was started again with a modified "eight drugs in 1 day" regimen [7]. Subsequently, the bone marrow infiltrate disappeared and the cells in the cerebrospinal liquid decreased to 51 x 106/liter.…”

Recurrent Glioblastoma Treated by Chemotherapy Alone

“…(1) has encouraging effects (2,3). It consists of 8 water-and lipid-soluble drugs, cycle-active and -independent, sequenced to take advantage of synergistic additive antitumoural mechanisms, and given in 1 day ("8 drugs in 1 day") to decrease myelosuppression.…”