Present investigation comprises of synthesis of a novel proline containing cyclic heptapeptide -Euryjanicin A, which was previously isolated from the marine spongeProsuberites laughlini. Naturally isolated cyclic heptapeptide was synthesized using solution phase peptide technique. All the coupling reactions were performed at room temperature via 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) -coupling reagent and triethylamine (Et 3 N) -base. The chemical structure of the finally synthesized cyclic heptapeptide was elucidated using FTIR, 1 H & 13 C NMR and mass spectral data, as well as elemental analyses. The newly synthesized peptide was subjected to anticancer activity against HeLa (Human Colon) cancer cell line and showed potent anticancer activity. ª 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Radio frequency identification (RFID) based electronic voting machine (EVM) with fingerprint module overcomes the challenges of wired electronic voting. Finger print module is to authenticate the voters. In this paper the system is constructed with microcontroller, Liquid Crystal Display (LCD), RS232 cable, RFID reader, RFID tag, fingerprint module and buzzer alarm. Dishonest voting will be avoided if the government uses the biometric based system. The details of all voters with their fingerprint will be stored in the database. Database is kept in microcontroller. Microcontroller verifies the voter by comparing the database during polling. If a person with RFID comes for second time voting, immediately the buzzer gives sound. The RFID base EVM will reduce time consumption. When compared to the existing voting system, the system in this paper is expected to be fast and reliable. The voters’ details will not be revealed out. For every polling end, the button should be pressed for getting the number of votes polled.
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