The basic requirements to auxiliary substances used in the technology of soft medicinal forms (ointments, gels, liniments, and creams) are formulated and a classification of such substances with respect to their technological properties is given. The composition of each particular soft medicinal form has to be selected and optimized taking into account the physicochemical, biopharmaceutical, and technological properties of all auxiliary components. 497 0091-150X/05/3909-0497
New soft medicinal forms (0.5% gel and liniment) of the antiviral phytodrug hiporamin have been developed on the basis of arespol. Experimental toxicological characterization of the new preparations was carried out on Chincilla rabbits by means of eight-week applications onto depilated back skin areas. Both gel and liniment of hiporamin were well tolerated by the animals with no manifestations of general toxicity and local irritant action.
Глубокие эвтектические растворители (ГЭР) представляют собой смеси, температура плавления которых ниже, чем у отдельных их компонентов. Уникальные свойства ГЭР позволяют говорить о них как о совершенно новых веществах с еще не раскрытыми потенциальными достоинствами и недостатками. Данный обзор включает описание истории изучения ГЭР, их свойств и характеристик, физико-химических параметров, информацию о токсикологическом профиле, а также взгляд на дальнейшие перспективы применения.
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