Auxiliary Substances Used in Technology of Soft Medicinal Forms: Ointments, Gels, Liniments, and Creams (A Review)

Abstract

The basic requirements to auxiliary substances used in the technology of soft medicinal forms (ointments, gels, liniments, and creams) are formulated and a classification of such substances with respect to their technological properties is given. The composition of each particular soft medicinal form has to be selected and optimized taking into account the physicochemical, biopharmaceutical, and technological properties of all auxiliary components. 497 0091-150X/05/3909-0497

Разработка Состава И Технологии Геля На Основе Карбомера

“…Наиболее широко распространенным механизмом загущения являются нейтрализация полимера подходящим основанием. В качестве нейтрализующих агентов используют гидроксид натрия, калия, аммония, а также органические амины и алканоамины: триэтаноламин, аминометилпропанол, трометамин [7]. Методы.…”

Market Analysis of Semisolid Dosage Forms Registered in Ukraine and Research of Excipients Included to Their Formulas

“…release, absorption and nature of their act, and also DF technology. Due to the ability to interact with the water, the basics are divided into hydrophilic, hydrophobic (lipophilic) and diphilic (hydrophiliclipophilic) [11,12].…”

“…Often, in order to obtain a specific pharmacological effect and maximum resistance DF it can be used several emulsifiers with different HLB values. To stabilize the direct emulsion, HLB emulsifiers are used less than 10, and for the inverse emulsion, HLB value should be greater than 10 [12].…”

“…Today, the range of antimicrobial preservatives that are approved for use is wide enough, but developing SDF manufacturers prefer parabens (nipahin, nipazol), benzoic acid and its salts, sorbic acid and its salts [12,22].…”