No abstract

(Abstracted from Lancet Oncol 2017;18:384–392) In more than 75% of women with endometrial cancer, the disease is confined to the uterus. Recurrence risk is defined by surgical staging with lymphadenectomy and helps in the decision to give adjuvant treatment to high-risk patients.

No abstract

Although overexpression of p53 protein, p53 gene mutations, and abnormal DNA content were similar between EOMs and POCs, EOMs demonstrated almost twice the rate of HER-2/neu overexpression. This result suggests that distinct genetic events may be responsible for malignant transformation in EOMs versus POCs.

Although the delta A mutation is a frequent event in sporadic MSI-positive endometrial cancers, it may not be causally associated with defective DNA MMR.