A case‐matched molecular comparison of extraovarian versus primary ovarian adenocarcinoma

Abstract

Although overexpression of p53 protein, p53 gene mutations, and abnormal DNA content were similar between EOMs and POCs, EOMs demonstrated almost twice the rate of HER-2/neu overexpression. This result suggests that distinct genetic events may be responsible for malignant transformation in EOMs versus POCs.

A Huge Primary Peritoneal Papillary Adenocarcinoma Which Demonstrated Imaging Findings Similar to Those of Extrahepatic-Growing Type Hepatic Tumor: Report of a Case

“…4 This tumor was first reported in 1959, under the name of mesothelioma of the peritoneum resembling papillary cystadenocarcinoma of the ovary, by Swerdlow. 5 This disease occurs almost exclusively in women and has been reported under different names such as extraovarian primary peritoneal carcinoma, 4 serous surface papillary carcinoma, 6 multiple focal extraovarian serous carcinoma, 7 primary peritoneal papillary serous adenocarcinoma, 8 serous surface carcinoma of the peritoneum, 9 extraovarian peritoneal serous papillary carcinoma, 10 extraovarian mullerian adenocarcinoma, 11 normal-sized ovary carcinoma syndrome, 12 papillary serous carcinoma of the peritoneum, 13 and peritoneal papillary carcinoma. 14 Primary peritoneal papillary carcinoma is Fig.…”

Papillary serous carcinoma of the peritoneum: analysis of clonality of peritoneal tumors

“…27 In particular, primary peritoneal carcinoma, including PSCP, demonstrates a high incidence (48% to 83%) of overexpression of p53 proteins in immunohistochemistry, and 9% or all of patients with primary peritoneal carcinoma revealed p53 gene mutations. [28][29][30] Most p53 gene alterations are missence mutations, and, in 560 reported mutations, 87% were found in exons 5 to 8, 8% in exon 4, and 4% in exon 10. 27 To date, p53 mutations in primary peritoneal carcinoma, including PSCP, have been found in exons 5 to 8 in all cases examined, except for those patients in whom no mutations were shown.…”

“…27 To date, p53 mutations in primary peritoneal carcinoma, including PSCP, have been found in exons 5 to 8 in all cases examined, except for those patients in whom no mutations were shown. 12,28,29 Hot spots and the timing of p53 gene mutation in the carcinogenesis of PSCP have not yet been determined.…”

Serous ovarian, fallopian tube and primary peritoneal cancers: A common disease or separate entities — A systematic review

“…Immunohistochemical studies Table 3 presents results from immunohistochemical protein expression studies in PPC cases, which compare the expression levels with corresponding results in OC cases from other studies [19,25,[27][28][29].…”