The frontoparietal network (FPN), including bilateral frontal eye field, inferior parietal sulcus, and supplementary motor area, has been linked to attention processing, including spatiotemporal and sensory modality domains. However, it is unclear whether FPN encodes representations of these domains that are generalizable across subdomains. We decomposed multivariate patterns of functional magnetic resonance imaging activity from 20 participants into domain-specific components and identified latent multivariate representations that generalized across subdomains. The 30 experimental conditions were organized into unimodal–bimodal and spatial–temporal models. We found that brain areas in the FPN, form the primary network that modulated during attention across domains. However, the activation patterns of areas within the FPN were reorganized according to the specific attentional demand, especially when pay attention to different sensory, suggesting distinct regional neural representations associated with specific attentional processes within FPN. In addition, there were also other domain-specific areas outside the FPN, such as the dorsolateral prefrontal cortex. Our conclusion is that, according to the results of the analysis of representation similarity, 2 types of activated brain regions, related to attention domain detailed information processing and general information processing, can be revealed.
COVER ILLUSTRATION In our study, we explored the change of neuron coupling relationship between oxygen and glucose metabolism (lower left) among normal controls, preclinical Alzheimer's disease (preAD) and cognitive impairments (CI) subjects (upper right). The oxygen metabolism was represented by the fractional amplitude of low‐frequency fluctuations (fALFF) and the regional homogeneity (ReHo) from resting‐state functional magnetic resonance imaging (rs‐fMRI) (upper left). The glucose metabolism was the standard uptake value ratio (SUVR) calculated from [18F] fluorodeoxyglucose positron emission tomography (18F‐FDG PET) (lower right). Our results indicated the coupling relationship based on ReHo and SUVR changed during the preAD stage in the default mode network (DMN) area, and it could be a novel potential biomarker for PreAD (center).
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