Cover Image

Abstract

COVER ILLUSTRATION In our study, we explored the change of neuron coupling relationship between oxygen and glucose metabolism (lower left) among normal controls, preclinical Alzheimer's disease (preAD) and cognitive impairments (CI) subjects (upper right). The oxygen metabolism was represented by the fractional amplitude of low‐frequency fluctuations (fALFF) and the regional homogeneity (ReHo) from resting‐state functional magnetic resonance imaging (rs‐fMRI) (upper left). The glucose metabolism was the standard uptake value ratio (SUVR) calculated from [18F] fluorodeoxyglucose positron emission tomography (18F‐FDG PET) (lower right). Our results indicated the coupling relationship based on ReHo and SUVR changed during the preAD stage in the default mode network (DMN) area, and it could be a novel potential biomarker for PreAD (center).