Microwave ablation at 2.45 GHz is gaining popularity as an alternative therapy to hepatic resection with a higher overall survival rate than external beam radiation therapy and proton beam therapy. It also offers better long-term recurrence-free overall survival when compared with radiofrequency ablation. To improve the design and optimization of microwave ablation procedures, numerical models can provide crucial information. A three-dimensional model of the antenna and targeted tissue without homogeneity assumptions are the most realistic representation of the physical problem. Due to complexity and computational resources consumption, most of the existing numerical studies are based on using two-dimensional axisymmetric models to emulate actual three-dimensional cancers and surrounding tissue, which is often far from reality. The main goal of this study is to develop a fully three-dimensional model of a multislot microwave antenna immersed into liver tissue affected by early-stage hepatocellular carcinoma. The geometry of the tumor is taken from the 3D-IRCADb-01 liver tumors database. Simulations were performed involving the temperature dependence of the blood perfusion, dielectric and thermal properties of both healthy and tumoral liver tissues. The water content changes during the ablation process are also included. The optimal values of the input power and the ablation time are determined to ensure complete treatment of the tumor with minimal damage to the healthy tissue. It was found that a multislot antenna is designed to create predictable, large, spherical zones of the ablation that are not influenced by varying tissue environments. The obtained results may be useful for determining optimal conditions necessary for microwave ablation to be as effective as possible for treating early-stage hepatocellular carcinoma, with minimized invasiveness and collateral damages.
Knowledge of the frequency dependence of the dielectric properties of the lung tissues and temperature profiles are essential characteristics associated with the effective performance of microwave ablation. In microwave ablation, the electromagnetic wave propagates into the biological tissue, resulting in energy absorption and providing the destruction of cancer cells without damaging the healthy tissue. As a consequence of the respiratory movement of the lungs, however, the accurate prediction of the microwave ablation zone has become an exceptionally demanding task. For that purpose, numerical modeling remains a primordial tool for carrying out a parametric study, evaluating the importance of the inherent phenomena, and leading to better optimization of the medical procedure. This paper reports on simulation studies on the effect of the breathing process on power dissipation, temperature distribution, the fraction of damage, and the specific absorption rate during microwave ablation. The simulation results obtained from the relative permittivity and conductivity for inflated and deflated lungs are compared with those obtained regardless of respiration. It is shown that differences in the dielectric properties of inflated and deflated lungs significantly affect the time evolution of the temperature and its maximum value, the time, the fraction of damage, and the specific absorption rate. The fraction of damage determined from the degree of tissue injury reveals that the microwave ablation zone is significantly larger under dynamic physical parameters. At the end of expiration, the ablation lesion area is more concentrated around the tip and slot of the antenna, and the backward heating effect is smaller. The diffuse increase in temperature should reach a certain level to destroy cancer cells without damaging the surrounding tissue. The obtained results can be used as a guideline for determining the optimal conditions to improve the overall success of microwave ablation.
This paper is focused on experimental testing and modeling of genuine leather used for a motorcycle personal protective equipment. Simulations of powered two wheelers (PTW) accidents are usually performed using human body models (HBM) for the injury assessment equipped only with the helmet model. However, the kinematics of the PTW rider during a real accident is disturbed by the stiffness of his suit, which is normally not taken into account during the reconstruction or simulation of the accident scenario. The material model proposed in this paper can be used in numerical simulations of crash scenarios that include the effect of motorcyclist rider garment. The fitting procedure was conducted on 2 sets of samples: 5 uniaxial samples and 5 biaxial samples. The experimental characteristics were used to obtain the set of 25 constitutive material models in terms of Ogden parameters.
In the recent years, we observe huge effort to develop new technologies for modern road vehicles in order to improve the level of safety for all passengers in the vehicle. Many of these systems are sooner or later becoming mandatory for the vehicles to be allowed to drive on the European roads. These are for example Lane Keeping Assistants (LKA) or Intelligent Speed Assist (ISA). Although there is huge effort on development and continuous improvement of these systems in the new vehicles, much less effort is put into the analysis of the infrastructure itself in the terms of its readiness for being used by these technologies. This study, in cooperation with the government authorities set as a goal an evaluation of sensoric readability of the horizontal and vertical road signs on the Slovak road infrastructure together with a public dataset to be released after the study will be completely done.
The article deals with the design and construction of an experimental device for measuring deviations in the thoracolumbar area of the human back. The article describes the devices construction, processing of measured data in the program MATLAB and the interpretation of the data in the form of a 3-D model. From this experimental device we would like to contribute to existing measuring devices with similar accuracy albeit in a more compact and user friendly package, which doesn't require a high degree of qualification to operate.
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