DNA interstrand cross-links (ICL) present a formidable challenge to the cellular DNA repair apparatus. For Escherichia coli, a pathway which combines nucleotide excision repair (NER) and homologous recombination repair (HRR) to eliminate ICL has been characterized in detail, both genetically and biochemically. Mechanisms of ICL repair in eukaryotes have proved more difficult to define, primarily as a result of the fact that several pathways appear compete for ICL repair intermediates, and also because these competing activities are regulated in the cell cycle. The budding yeast Saccharomyces cerevisiae has proven a powerful tool for dissecting ICL repair. Important roles for NER, HRR and postreplication/translesion synthesis pathways have all been identified. Here we review, with reference to similarities and differences in higher eukaryotes, what has been discovered to date concerning ICL repair in this simple eukaryote.
In the recent years, we observe huge effort to develop new technologies for modern road vehicles in order to improve the level of safety for all passengers in the vehicle. Many of these systems are sooner or later becoming mandatory for the vehicles to be allowed to drive on the European roads. These are for example Lane Keeping Assistants (LKA) or Intelligent Speed Assist (ISA). Although there is huge effort on development and continuous improvement of these systems in the new vehicles, much less effort is put into the analysis of the infrastructure itself in the terms of its readiness for being used by these technologies. This study, in cooperation with the government authorities set as a goal an evaluation of sensoric readability of the horizontal and vertical road signs on the Slovak road infrastructure together with a public dataset to be released after the study will be completely done.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.