ObjectiveThe present study evaluated the association between lactotransferrin (LTF) gene
polymorphism (exon 2, A/G, Lys/Arg) and dental caries.Material and MethodsA convenience sample of 110 individuals, 12 years old, was divided into: group 1,
48 individuals without caries experience (DMFT=0), and group 2, 62 subjects with
caries experience (DMFT≥1). DNA was obtained from a mouthwash with 3%
glucose solution, followed by a scrapping of the oral mucosa. After DNA
purification, polymerase chain reaction (PCR), single strand conformation
polymorphism (SSCP) was performed to access the study polymorphism. The LTF A/G
(Lys/Arg) polymorphism had been previously reported as located in exon 1.ResultsAllele 1 of the study polymorphism was associated with low DMFT index and showed a
protective effect against caries experience (OR=0.16, IC=0.030.76, p=0.01).ConclusionLactotransferrin A/G (exon 2, Lys/Arg) polymorphism was associated with
susceptibility to dental caries in 12-year-old students.
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