Nota: Estas diretrizes se prestam a informar e não a substituir o julgamento clínico do médico que, em última análise, deve determinar o tratamento apropriado para seus pacientes.

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SummaryObjectives: Estimate the prevalence of hypertension and some cardiovascular risk factors in the adult population of a major city in Brazil.Methods: Descriptive, observational, transversal population-based study substantiated by the home survey of a simple random sample (>18 years old). Standardized questionnaires were used to obtain sociodemographic information, measurements of blood pressure (2 measurements), weight, height, and abdominal circumference (AC). Microsoft Access and Epi Info 6 were used for data storage and analysis, respectively. The last blood pressure reading was used (hypertension: BP≥140x90mmHg).Results: The study evaluated 1,739 individuals (87% of the estimated sample). There was a predominance of females (65.4%) and mean age was 39.7 years (±15.6); arterial hypertension prevalence was 36.4%, higher for the male population (41.8%) when compared to females (31.8%). Correlation between Hypertension and Body Mass Index was positive, as well as with AC and age. The female gender and higher income were protective factors against hypertension. Prevalence of overweight and obesity were 30.0% and 13.6%, respectively; overweight was higher among females and obesity among males. The prevalence of smoking was 20.1%, more frequent among males (27.1%), when compared to females (16.4%). A sedentary lifestyle was observed in 62.3% of the population, with no difference between the genders. Regular alcohol consumption was reported by 44.4% of the individuals, being more frequent in males.Conclusion: Hypertension and other cardiovascular risk factors (particularly overweight/obesity) indicators are high, reinforcing the need for objective nationwide measures to fight this disease, in order to reduce CVD morbidity and mortality.

Background: Systemic Arterial Hypertension (SAH), considered a public health problem due to its high prevalence and difficult control, is also described as one of the most important risk factors for cardiovascular diseases.

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BackgroundPrehypertension is associated with higher cardiovascular risk, target organ damage, and incidence of hypertension. The Prevention of Hypertension in Patients with PreHypertension (PREVER‐Prevention) trial aimed to evaluate the efficacy and safety of a low‐dose diuretic for the prevention of hypertension and end‐organ damage.Methods and ResultsThis randomized, parallel, double‐blind, placebo‐controlled trial was conducted in 21 Brazilian academic medical centers. Participants with prehypertension who were aged 30 to 70 years and who did not reach optimal blood pressure after 3 months of lifestyle intervention were randomized to a chlorthalidone/amiloride combination pill or placebo and were evaluated every 3 months during 18 months of treatment. The primary outcome was incidence of hypertension. Development or worsening of microalbuminuria, new‐onset diabetes mellitus, and reduction of left ventricular mass were secondary outcomes. Participant characteristics were evenly distributed by trial arms. The incidence of hypertension was significantly lower in 372 study participants allocated to diuretics compared with 358 allocated to placebo (hazard ratio 0.56, 95% CI 0.38–0.82), resulting in a cumulative incidence of 11.7% in the diuretic arm versus 19.5% in the placebo arm (P=0.004). Adverse events; levels of blood glucose, glycosylated hemoglobin, creatinine, and microalbuminuria; and incidence of diabetes mellitus were no different between the 2 arms. Left ventricular mass assessed through Sokolow‐Lyon voltage and voltage‐duration product decreased to a greater extent in participants allocated to diuretic therapy compared with placebo (P=0.02).ConclusionsA combination of low‐dose chlorthalidone and amiloride effectively reduces the risk of incident hypertension and beneficially affects left ventricular mass in patients with prehypertension.Clinical Trial Registration URL: http://www.ClinicalTrials.gov, www.ensaiosclinicos.gov. Unique identifiers: NCT00970931, RBR‐74rr6s.

OBJETIVO: Avaliar a associação entre marcadores antropométricos de adiposidade corporal (índice de massa corporal e circunferência da cintura) e hipertensão arterial. MÉTODOS: Estudo de corte transversal, de base populacional, realizado no período de 2003 a 2004, com 1.298 indivíduos de 20 a 59 anos. Foram considerados hipertensos os indivíduos com pressão arterial > 140/90 mmHg ou em uso de medicação anti-hipertensiva. As associações entre os indicadores antropométricos e a hipertensão arterial foram analisadas por regressão de Poisson, ajustada por potenciais fatores de confusão (sexo, idade, escolaridade, tabagismo, consumo de bebida alcoólica e atividade física no lazer). A curva ROC foi utilizada para determinar o melhor ponto de corte do IMC para detecção da hipertensão arterial. RESULTADOS: A prevalência de hipertensão arterial foi de 28,3%, sendo 33,5% no sexo masculino e 23,5% no feminino. Após ajuste para o IMC e potenciais fatores de confusão, a circunferência da cintura perdeu associação com o desfecho avaliado, permanecendo apenas o IMC com poder de explicação para a hipertensão arterial (RP = 1,05, p = 0,001). O melhor ponto de corte para o IMC no sexo masculino foi de 25,6 Kg/m², e no sexo feminino 25,7 Kg/m². CONCLUSÕES: A associação observada entre a circunferência da cintura e a hipertensão arterial em muitos estudos pode estar relacionada à ausência de controle de potenciais fatores de confusão nas análises, bem como à não remoção do efeito da adiposidade total. Novas investigações devem ser conduzidas na população brasileira, a fim de se verificar as verdadeiras associações entre indicadores antropométricos e vários desfechos, estudando-se também os melhores pontos de corte desses indicadores.