The impairment in weight and length was more severe in cleft lip + palate and isolated cleft palate children and may be attributed to feeding difficulties compared to the isolated cleft lip group.

Objective: To analyze the differences in growth impairment according to sex in the 2 first years of life in children with three types of clefts.Methods: This was a cross-sectional study of 881 children (58.9% boys and 41.1% girls) with cleft lip and palate treated at the Craniofacial Anomaly Rehabilitation Hospital, (University of São Paulo, Bauru, SP), Brazil. Age ranged from 1 to 24 months. Three types of clefts were evaluated: isolated cleft lip (181/20.5%), isolated cleft palate (157/17.8%) and cleft lip + palate (543/61.6%). Weight and length measurements and data regarding breast-feeding and socioeconomic level were obtained. Children with weight and length below the 10th percentile of the NCHS reference were considered to have impaired growth.Results: Sample distribution according to cleft type and sex was similar to that observed in other epidemiological studies. Breastfeeding was more frequent in the isolated cleft lip group (45.9%) then in the isolated cleft palate (12.1%) or cleft lip + palate group (10.5%). Isolated cleft lip children showed less marked impairment of weight (23.8%) and length (19.3%) compared to the cleft lip + palate group (35.7% and 33.1%, respectively). In the latter group, the proportion of children with weight and length below the 10th percentile was very close to that of the isolated cleft palate group (34.4% and 38.9%). Conclusions:The impairment in weight and length was more severe in cleft lip + palate and isolated cleft palate children and may be attributed to feeding difficulties compared to the isolated cleft lip group.J Pediatr (Rio J). 2005;81(6):461-5: Breast-feeding, auxology, nutrition. ResumoObjetivo: Analisar as diferenças no prejuízo do crescimento até os 2 anos de idade, de acordo com o sexo, entre crianças com três tipos de fissuras lábio-palatinas.Métodos: Trata-se de estudo transversal de 881 crianças (58,9% meninos e 41,1% meninas) com fissura lábio-palatina, atendidas no Hospital de Reabilitação de Anomalias Craniofaciais, Universidade de São Paulo, Bauru (SP), com idade entre 1 e 24 meses. Três tipos de fissuras foram avaliados: lábio isolada (181/20,5%), palato isolada (157/17,8%) e lábio+palato (543/61,6%). Foram obtidas medidas de peso e comprimento e informações referentes a aleitamento materno e condições socioeconômicas. Crianças com peso e comprimento abaixo do 10 o percentil da referência do NCHS foram consideradas de risco para crescimento prejudicado.Resultados: A distribuição da amostra segundo tipo de fissura e sexo foi semelhante ao observado em outros estudos epidemiológicos. O aleitamento materno foi mais freqüente entre crianças com fissura labial isolada (45,9%) do que nas de fissura palatina isolada (12,1%) ou fissura de lábio+palato (10,5%). Crianças com fissura labial isolada apresentaram menor comprometimento do peso (23,8%) e comprimento (19,3%), quando comparadas ao grupo de fissura de lábio+palato (35,7% e 33,1%, respectivamente), sendo que este apresentou proporções de crianças com peso e comprimento abaixo do 10 o percentil...

We report a 6-month-old boy, born of consanguineous (first-cousin) parents (F = 1/16) presenting microbrachycephaly, wide forehead, marked hypertelorism, broad nose with a midline groove with a bilateral small "blind dimple" in each side, hypospadias, syndactyly between fingers 3 and 4, broad thumbs, and halluces. This association of anomalies suggests the diagnosis of a "new" type of acro-fronto-facio-nasal dysostosis. Normal chromosomes, parental consanguinity, and familial occurrence suggest autosomal recessive inheritance.