tration with CD43-and ED1-positive cells in glomeruli and Mycophenolate mofetil prevents the progressive renal failure interstitium was two to five times lower in MMF-treated rats induced by 5/6 renal ablation in rats.(P Ͻ 0.01). Expression of adhesion molecules CD18 and CD11b Background. Extensive renal ablation is associated with prowas similarly reduced. gressive sclerosis of the remnant kidney. Because lymphocytes Conclusion. MMF ameliorates the progressive renal damage and monocytes accumulate in the remnant kidney, it is likely that they play a role in the renal scarring. Therefore, we treated in the remnant kidney after 5/6Nx. This effect is associated with rats with 5/6 nephrectomy (5/6Nx) with mycophenolate mofetil a reduction in the infiltration of lymphocytes and monocytes, (MMF), a drug that has an antiproliferative effect and that whereas glomerular hypertrophy and systemic hypertension suppresses the expression of intercellular adhesion molecules. are unchanged. Methods. Sprague-Dawley rats with 5/6Nx received MMF (30 mg • kg Ϫ1 • day Ϫ1 by daily gastric gavage, N ϭ 15) or vehicle
un artículo de acceso abierto distribuido bajo los términos de la Licencia Creative Commons, que permite uso ilimitado, distribución y reproducción en cualquier medio, siempre que la obra original es debidamente citada.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.