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Sahelian West Africa is a region of high year-to-year climate variability that can significantly impact on communities and livelihoods. Adaptive social protection (ASP) is being introduced in the region to support vulnerable people through enabling more effective responses to climate shocks, bridging social protection with disaster risk reduction and climate change adaptation. The ASPIRE (Adaptive Social Protection: Information for enhanced REsilience) project aimed to provide technical support to the World Bank's Sahel Adaptive Social Protection Programme through demonstrating the use of climate forecasts in ASP and promoting dialogue between climate and social protection stakeholders.Here we discuss lessons learned in the project, highlighting challenges and opportunities for including climate forecasts in early warning systems to inform ASP. We provide recommendations to help achieve ASP systems designed to use climate forecasts, arguing that tailored seasonal forecast products have potential in some countries to improve the lead time of interventions to address climate-induced disasters. Critical to this is continued investment in underpinning science and capacity building of climate and social protection stakeholders, as well as strengthened dialogue between actors to co-develop climate forecasts that provide actionable information.

Background: Immune-checkpoint inhibitors (ICIs) have increased and improved the treatment options for patients with non-oncogene-addicted advanced stage non-small cell lung cancer (NSCLC). However, the role of ICIs in oncogene-addicted advanced stage NSCLC patients is still debated. In this study, in an attempt to fill in the informational gap on the effect of ICIs on other driver mutations, we set out to provide a molecular landscape of clinically relevant oncogenic drivers in programmed death-ligand 1 (PD-L1) positive NSCLC patients. Methods: We retrospectively reviewed data on 167 advanced stage NSCLC PD-L1 positive patients (≥1%) who were referred to our clinic for molecular evaluation of five driver oncogenes, namely, EGFR, KRAS, BRAF, ALK and ROS1. Results: Interestingly, n = 93 (55.7%) patients showed at least one genomic alteration within the tested genes. Furthermore, analyzing a subset of patients with PD-L1 tumor proportion score (TPS) ≥ 50% and concomitant gene alterations (n = 8), we found that n = 3 (37.5%) of these patients feature clinical benefit with ICIs administration, despite the presence of a concomitant KRAS gene alteration. Conclusions: In this study, we provide a molecular landscape of clinically relevant biomarkers in NSCLC PD-L1 positive patients, along with data evidencing the clinical benefit of ICIs in patient NSCLC PD-L1 positive alterations.

Background This paper examines the role of improved groundwater access and management in providing opportunities for sustainable agricultural intensification and building the resilience of community farmers in Southern Burkina Faso. The findings contribute to current debates about pathways of commercialisation and adaptation in the African Sahel, especially those seeking to find responses to managing the impacts of climate change and delivering on the Sustainable Development Goals. Methods This paper presents data that has been thematically analysed based on the Framework for Sustainable Intensification developed by Pretty and Bharucha (Ann Bot 114:1571–1596, 2014). The data used includes 144 Vulnerability Baseline Assessments which were conducted at the start of the project with the four target Burkinabe communities (Kado, Poa, Tomo, and Zhilivele), and 33 monitoring interviews and vulnerability assessments from the Burkinabe communities of Poa and Tomo to track progress and behaviour change resulting from the BRAVE project interventions. Results The data analysis showed that Burkinabe communities are already making some use of groundwater to support their agricultural livelihoods; most do this through accessing groundwater from shallow wells. It was also shown that there were improvements in the four main themes Identified by the Sustainable Intensification Framework. These included improved information sharing through increased peer-to-peer learning and improvements in confidence levels; improved social cohesion through reduction in community conflict over water resource management; asset improvements shown by tangible improvement of yields; and increased awareness exemplified by behaviour change. Conclusions Through using the Sustainable Intensification framework, this paper argues that such an approach improves essential aspects of resilience building such as information sharing, improved local governance and increased social capital and income. We argue that such changes provide essential pathways to reducing vulnerability and increasing resilience of at-risk communities in the Sahel, but that national policy alignment and investment is essential for long term change and sustainability.

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