The decision-making regarding and treatment of cartilage abnormalities requires a systematic approach. This article reviews the concepts and principles that guide the management of this complex problem. The precise incidence, demographics, and progression of cartilage lesions have not been clearly delineated. Pursuing a patient-centered approach that considers the available nonsurgical and surgical options remains the cornerstone of patient care. The importance of determining concomitant knee pathologies, the proper interpretation and implications of imaging findings, and an accurate determination of the intra-articular and subchondral findings represent the primary elements of the decision analysis. Treatment options vary depending on patient goals, the disposition of the lesion, and a variety of other factors. The authors recommend proper patient education and consideration of how nonsurgical treatment or less invasive options such as arthroscopic debridement might be effective. If these strategies should fail, appropriate matching of a surgical procedure to the patient's pathology, goals, and expectations is warranted. Surgical options include debridement, marrow stimulation techniques, surface allograft treatments, autologous chondrocyte implantation, and osteochondral grafting (autograft and allograft) in addition to some emerging technologies. This article focuses on the decision-making process. [Orthopedics. 2016; 39(6):343-350.].
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