Objective This single‐center, retrospective analysis investigated the clinical outcomes of a novel vascular closure device (VASCADE, Cardiva Medical, Santa Clara, CA) for closure of 7F femoral venotomies. Background The VASCADE closure device has been widely used to close arteriotomy sites following femoral procedures; however, little data have been published regarding the device's utility in closure of venotomy sites after procedures such as right‐heart catheterization. Methods This was a retrospective analysis of outcomes in 102 consecutive patients who underwent venous closure using the VASCADE device following diagnostic right and left‐heart catheterization between April 2016 to May 2018. Patients’ age, gender, valvular disease status, comorbidities, and periprocedural use of antiplatelet/anticoagulant therapy were analyzed. Results Closure was successful in 99% (101/102) of patients with respect to achieving the primary outcome of rapid hemostasis in ≤3 min. There was one device failure requiring manual compression, with no further complications. There were no other related adverse events or complications through 30 days of follow‐up. Conclusions The VASCADE device achieved venous hemostasis in nearly all our patients. We believe devices for venous closure can aid in improving patient experience, safety, and efficiency during these procedures.
RATIONALE: CD4+IL-4+ T cells are required for human and murine IgE responses. We reported that CD4+ T cells and CD8+CD60+ T cells and six cytokines 4,6,10,12,IFNa,IFNg) are required for induction of ragweed specific memory IgE responses. Antigen cleaves complement and human CD4+ T cells express receptors for CSP. Receptors for CSP C3a and C5a on CD8+CD60+ T cells have not been reported. METHODS: CD4+CD3+ and CD8+CD60+CD45RO6CD45RA6IL-46IFNg6 T cells in blood of serum IgE+ (fluoroimmunoassay) ragweed sensitized (RS) and IgE-nonallergic humans expressing receptors for CSP C3a and C5a (CD88) (n52-3/group) were determined by flow cytometry. Data expressed as mean % total lymphocytes and % subset. RESULTS: Blood of IgE+ RS humans contained increased numbers of CD4+ and CD8+CD60+ T cells expressing receptors for C3a (36, 85%, respectively), compared with IgE-nonallergic humans (16, 36%, respectively). Further, in IgE+, but not IgE-humans, both T cell subsets expressed greatly increased C3a receptors/cell (MESF). In IgE+ humans, virtually all CD8+CD60+ T cells were CD45RO+CD45RA-and IL-4+IFNg-; in IgE-humans they were virtually all IL-4-, with CD45RA+ cells predominating. Neither CD4+ nor CD8+CD606 T cells of either IgE+ or IgE-humans expressed receptors for CSP C5a (CD88) (<1%). CONCLUSIONS: The presence of receptors for C3a on CD4+ and CD8+CD60+CD45RO+ IL-4+ T cells required for induction of ragweed specific memory IgE responses suggests that C3a may play an important role in induction of these responses.
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