CD4+ and CD8+CD60+CD45RO+IL-4+IFNγ- T Cells Expressing Receptors for Complement Split Product (CSP) C3a, but Not C5a, Are Increased in Blood of Serum IgE+, Compared With Serum IgE- Adults
Abstract:RATIONALE: CD4+IL-4+ T cells are required for human and murine IgE responses. We reported that CD4+ T cells and CD8+CD60+ T cells and six cytokines 4,6,10,12,IFNa,IFNg) are required for induction of ragweed specific memory IgE responses. Antigen cleaves complement and human CD4+ T cells express receptors for CSP. Receptors for CSP C3a and C5a on CD8+CD60+ T cells have not been reported. METHODS: CD4+CD3+ and CD8+CD60+CD45RO6CD45RA6IL-46IFNg6 T cells in blood of serum IgE+ (fluoroimmunoassay) ragweed sensitize… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.