The abnormal brain discharges observed in benign childhood epilepsy with centrotemporal spikes (BECTS) and temporal lobe epilepsy (TLE) are located close to areas responsible for auditory and language processing. This study aimed to analyze the results of auditory event-related potentials (P300) in children with BECTS and TLE in order to assess whether the epileptic activity in centrotemporal and temporal regions may compromise the integrity and physiology of auditory system structures. This was a prospective, comparative, and cross-sectional study. Group I (GI) consisted of 13 children diagnosed with BECTS, group II (GII), 7 children diagnosed with TLE, and control group (GIII), 16 healthy children, with no hearing or academic complaints. After neurological and basic audiological assessments, P300 was applied. The P300 latency and amplitude were compared between groups. Regarding latency, GI showed 324.1 (+31.5) ms, GII 336.3 (+23.5) ms, and GIII 318 (+27.7) ms. Amplitudes were 4.80 (+3.2) μV in GI, 4.7 (+2.5) μV in GII, and 5.8 (+2.4) μV in GIII. Although children with BECTS showed prolonged latencies and reduced amplitudes, these differences were not considered statistically significant. Children with TLE showed statistically significant prolonged P300 latency compared with the control group (P=0.037). We speculate that abnormal electrical discharges in centrotemporal and temporal regions led to the slowing of auditory processing in our sample.
The aim of this research was to analyze temporal auditory processing and phonological awareness in school-age children with benign childhood epilepsy with centrotemporal spikes (BECTS). Patient group (GI) consisted of 13 children diagnosed with BECTS. Control group (GII) consisted of 17 healthy children. After neurological and peripheral audiological assessment, children underwent a behavioral auditory evaluation and phonological awareness assessment. The procedures applied were: Gaps-in-Noise test (GIN), Duration Pattern test, and Phonological Awareness test (PCF). Results were compared between the groups and a correlation analysis was performed between temporal tasks and phonological awareness performance. GII performed significantly better than the children with BECTS (GI) in both GIN and Duration Pattern test (P < 0.001). GI performed significantly worse in all of the 4 categories of phonological awareness assessed: syllabic (P = 0.001), phonemic (P = 0.006), rhyme (P = 0.015) and alliteration (P = 0.010). Statistical analysis showed a significant positive correlation between the phonological awareness assessment and Duration Pattern test (P < 0.001). From the analysis of the results, it was concluded that children with BECTS may have difficulties in temporal resolution, temporal ordering, and phonological awareness skills. A correlation was observed between auditory temporal processing and phonological awareness in the suited sample.
It is assumed that 25% of patients with epilepsy are women of fertile age and 0.3% to 0.6% of all children are born of mothers with epilepsy. The aim of this study was to evaluate the quality of life on pregnant with epilepsy and compare with non-pregnant women with epilepsy. We evaluated two groups (Experimental Group -29 pregnant women with epilepsy and Control Group -30 women with epilepsy); they were attended at the HC/ UNICAMP. The patients had three meetings to carry out and implement the anamnesis and the application of QQV-65. There were no significant differences in the measurement of quality of life when comparing both groups. However, when we analyzed individually in the pre-and post-partum periods, we observed significant differences in health aspects (p=0.0495), physical (p=0.02868) and emotional (p=0.0253) dimensions in QQV-65. This study shows that pregnancy could be interpreted as a stressor. In late pregnancy when this stressor was removed, women with epilepsy had improvement in their quality of life. Key words: women, pregnancy, quality of life, epilepsy.Qualidade de vida em gestantes com epilepsia versus mulheres com epilepsia RESUMO Admite-se que 25% dos pacientes com epilepsia sejam mulheres em idade fértil e que 0,3% a 0,6% de todas as crianças nascidas sejam filhas de mães epilépticas. O objetivo do presente estudo foi avaliar a qualidade de vida em gestantes com epilepsia e compará-la com a de mulheres com epilepsia não grávidas. Foram avaliados dois grupos (Grupo Experimental -29 gestantes com epilepsia e Grupo Controle -30 mulheres com epilepsia) atendidos no HC/UNICAMP. As pacientes foram submetidas a três encontros para a realização de anamnese e a aplicação do QQV-65. Não encontramos diferenças significativas na avaliação de qualidade de vida ao comparar ambos os grupos. No entanto quando avaliados individualmente no período pré e pós-natal, observamos diferenças significativas nos aspectos: saúde (p=0,0495), físico (p=0,02868) e emocional (p=0,0253) no QQV-65. Este estudo mostrou que a gravidez pode ser interpretada como um estressor. No final da gravidez, quando este estressor foi removido, mulheres com epilepsia mostraram melhora na qualidade de vida. Palavras-chave: mulheres, gravidez, qualidade de vida, epilepsia.
OpinionDear Editor, I read the recent report on pregnancy, epilepsy and quality of life with a great interest 1 . Lunardi et al. concluded that "pregnancy could be interpreted as a stressor 1" and "In late pregnancy when this stressor was removed, women with epilepsy had improvement in their quality of life . " There are several concerns on this work. First, few subjects with imbalance controls might mean bias and statistically unacceptability. Quality of life might be the result of many factors rather than pregnancy and epilepsy. The adjustment for confounding factors especially for socioeconomic status is required. Second, it is required to further study on the level of quality of life and the exact episode of epilepsy, during pregnancy and before pregnant period. In addition, the stess as mentioned by the authors should be further considered in the postpartum period. The "blue" or pospartum stress is also mentioned as a factor impairing quality of life of the women with epilepsy GRAVIDEZ, EPILEPSIA E QUALIDADE DE VIDAViroj Wiwanitkit -Wiwanitkit House, Bangkhae, Bangkok Thailand 10160. E-mail: wviroj@yahoo.com ReplyDear Editor, Our study shows the first results with women with epilepsy (WWE) in whom pregnancy and it could be interpreted as a stressor with impact in their quality of life (QoL) 11. Several aspects can be discussed in our work: 1. The aim was to evaluate the QoL in pregnant women with epilepsy and to compare with non-pregnant women with epilepsy. This design that was sought to control the stressor of epilepsy (controlled variable) and pregnancy.2. Statistical analysis was carried out to compare the groups using the SAS Statistical Software (2002-2003; version 9).3. In the group of pregnant women that evaluated pre-and post partum, the subjects were own controls, not requiring adjustment for socio-demographic and disease variables.4. For comparison between groups of Qol could be an adjustment if we had found differences between them, which did not happen. Any adjustment would not change the results.QoL is a subjective measure and strongly controlled by intrapsychic variables. Several studies agree that it is the cognitive representations that control the responses of well-being and the presence of emotional disorder 1,2 rather than clinical or sociodemographic factors in epilepsy:1. Lunardi 2 has worried to identify in her work which stressors from pregnant would be controlling the responses of well-being (QoL) of the subjects.These were explained in the discussion. No women reported post partum depression.2. Souza e AL 3 , in a pilot study and now with larger number of subjects showed more stress in WWE in pre partum that decreased in postpartum but maintaining still high compared with the control group.3. Lunardi also compared levels of stress in three groups: pregnant women with epilepsy, pregnant women without epilepsy and women with epilepsy and showed more stress in the first group 2 . Our service has been working for multidisciplinary care to women with epilepsy since 2002 where there...
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