Hematologic abnormalities were studied prospectively in 38 patients with brucellosis. Anemia was found in 74% of patients, leukopenia in 45%, neutropenia in 21%, lymphopenia in 63%, and thrombocytopenia in 39.5%. Eight patients (21%) were pancytopenic; seven of these individuals also had splenomegaly. Bone marrow hypoplasia was not found. Bleeding complications developed in 26% of patients and were significantly associated with clotting abnormalities (low platelet count, low fibrinogen level, and/or prolongation of thrombin clotting time); i.e., bleeding occurred in approximately 50% of patients with marked clotting abnormalities but in no patients with normal clotting. Determination of fibrinogen levels at different stages of brucellosis led to a redefinition of the normal level for patients with this infection. Patients without clotting abnormalities had fibrinogen levels of 233-711 mg/100 ml (mean, 384 mg/100 ml), whereas patients with thrombocytopenia and prolonged thrombin clotting time had levels of 122-360 mg/100 ml (mean, 216 mg/100 ml; P less than .001) that increased to 233-519 mg/100 (mean, 360 mg/100 ml) when clotting values returned to normal. Lymphopenia was significantly correlated with the severity of clinical manifestations (bleeding and hepatic involvement).
Antecedentes: Este artículo emerge como parte de un proceso liderado por la Academia Nacional de Medicina del Perú en estrecha colaboración con otras Academias de Medicina Latinoamericanas, e importantes instituciones universitarias y profesionales relacionadas con la salud. Objetivo: Describir y fundamentar la importancia de la Medicina Centrada en la Persona (MCP) en el contexto latinoamericano. Metodología: Revisión de artículos y experiencias latinoamericanas sobre el tema, realización de reuniones académicas para deliberar sobre contenidos afines, dos preliminares en Lima en diciembre 2013 y enero 2014, una tercera en Buenos Aires, a propósito del 2° Congreso Internacional de Medicina Centrada en la Persona, con la presencia de las Academias de Medicina de Argentina, Bolivia, Chile y Perú (noviembre 2014) y una cuarta en Lima, Reunión de las Academias de Medicina de Bolivia, Colombia, Chile, Paraguay y Perú (diciembre 2014). Resultados: Se puntualizan los precedentes históricos y contemporáneos, universales y locales, pertinentes a la gestación y desarrollo de una re-priorización de la medicina en torno a la persona y su contexto, articulando para el efecto ciencia y humanismo. Se discute el nivel filosófico del concepto Persona en medicina, incluyendo bases terminológicas, históricas, y derechos humanos. Sobre estas bases se examina la evolución de los conceptos centrales de la MCP, resaltando su pertinencia tanto en la medicina clínica como en la salud pública, la atención, educación e investigación y las políticas en salud. Con respecto a la práctica y educación clínicas, se plantea la noción de MCP como principio estratégico fundamental, sus aplicaciones educacionales programáticas, y su posible institucionalización a nivel de facultades de medicina. Se resalta la importancia de la formación en ética y comunicación clínica y del apropiado uso de la tecnología y la evidencia científica al servicio de la persona. Se incluyen posibilidades institucionales disponibles para la educación inter-disciplinaria de los profesionales de la salud así como perspectivas educacionales latinoamericanas. Se destaca la importancia de la investigación científica sobre la MCP, abarcando estudios sobre conceptualización, medición y diagnóstico incluyendo la necesidad de elaborar instrumentos narrativos complementarios. Finalmente, se consideran perspectivas sobre políticas de salud centradas en la persona y la comunidad así como aportes y recomendaciones derivados de la experiencia latinoamericana en este tema. Conclusiones: La Medicina Centrada en la Persona valora los avances biológicos, psicológicos y socio-culturales y los procesa dentro del marco de la totalidad de la persona, articulando la ciencia como instrumento esencial y el humanismo como la esencia de la medicina. Frente a formulaciones epistemológicas reduccionistas, la MCP propone una medicina informada por la evidencia y la experiencia y orientada a la persona en su totalidad.
Background: This paper emerges as part of a process lead by the National Academy of Medicine of Peru in close collaboration with other Latin American National Academies of Medicine, major universities and health professional institutionsObjectives: To describe and substantiate the importance of Person Centered Medicine (PCM) in the Latin American context. Methodology: Review of Latin American scientific literature and experiences on this issue and organization of academic meetings to deliberate on related problems, two preliminary ones in Lima in December 2013 and January 2014, a third one in Buenos Aires at the Second International Congress of Person Centered Medicine with the participation of the National Academies of Medicine of Argentina, Bolivia, Chile and Peru (November, 2014), and a fourth in Lima with the presence of the National Academies of Medicine of Bolivia, Chile, Colombia, Paraguay and Peru (December, 2014). Results: Historical and contemporary, universal and local precedents to the gestation and development of a re-prioritization of medicine in relation to the Person in context are pointed out, articulating for such purpose science and humanism. The concept of Person in medicine from a philosophical point of view, including terminological, historical and human rights dimensions, are discussed. Upon these bases, the central concepts of PCM are considered, emphasizing its pertinence in clinical medicine as well as in public health, clinical care, education, research, and health policies. In regards to clinical education and practice, the PCM concept as a fundamental strategic principle, its programmatic educational applications and its institutionalization at a medical school level are proposed. The importance of ethical training and clinical communication as well as the appropriate use of technology and scientific evidence at the service of the Person are highlighted. Available institutional opportunities for health professional interdisciplinary education as well as Latin American educational perspectives are discussed. Scientific research on PCM is highlighted particularly concerning studies on conceptualization, measurement and diagnosis, including the need to construct narrative complementary instruments. Furthermore, perspectives on health policies centered on the person and the community are considered as well as contributions and recommendations derived from Latin American experience on this topic. Conclusions: PCM values biologic, psychological and socio-cultural scientific advances, processing them within the comprehensive framework of the Person, articulating science as an essential instrument and humanism as the essence of medicine. In contraposition to reductionist epistemological formulations, PCM proposes a medicine informed by evidence and experience and oriented towards the totality of the person.
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