The case is described of a 15-year-old patient that presented several pyoderma gangrenosum lesions 16 months before onset of rheumatoid arthritis manifestations. There was an excellent response to therapeutics using clofazimine. Keywords: Arthritis; Arthritis, reumatoid; Clofazimine; Clofazimine/therapeutic use; Pyoderma gangrenosum/drug therapy; Pyoderma gangrenosum/therapy; Case report.
Resumo
A síndrome das unhas frágeis é queixa comum, caracterizada por aumento da fragilidade das lâminas ungueais. Afeta quase 20% da população geral, sendo mais comum em mulheres. Clinicamente se manifesta com onicosquizia e onicorrexe - distúrbios nos fatores de adesão intercelular das unhas se manifestam como a primeira, ao passo que alterações da matriz apresentamse com onicorrexe. Mesmo sendo tão usual e afetando os pacientes de maneira importante em seu cotidiano, o tratamento das unhas frágeis avançou pouco nas últimas décadas e ainda se baseia principalmente no uso da biotina.
Cutaneous polyarteritis nodosa is the vasculitis affecting medium-sized vessels in the deep dermis and panniculus. It is characterized by tender nodules which may ulcerate, preceded, accompanied or followed by livedo reticularis. Its diagnosis is confirmed by clinical and histopathological findings. A case of a patient presenting a chronic form of the illness is described.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.