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A new model for mechanically induced red blood cell damage is presented. Incorporating biophysical insight at multiple length scales, the model couples flow-induced deformation of the cell membrane (similar to 10 mu m) to membrane permeabilization and hemoglobin transport (similar to 100 nm). We estimate hemolysis in macroscopic (above similar to 1 mm) 2-D inhomogeneous blood flow by computational fluid dynamics (CFD) and compare results with literature models. Simulations predict the effects of local flow field on RBC damage, due to the combined contribution of membrane permeabilization and hemoglobin transport. The multiscale approach developed here lays a foundation for a predictive tool for the optimization of hydrodynamic and hematologic design of cardiovascular prostheses and blood purification devices. (c) 2014 American Institute of Chemical Engineers AIChE J, 60: 1509-1516, 201

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Adsorption equilibrium of bilirubin onto polymeric resins is studied. Solutions containing albumin are used in order to simulate the behavior of systems for removal of albumin-bound substances from blood, serum or dialysis fluids. The effect of albumin pre-loading on the resin is also analysed. Results are explained by a chemically based model that accounts for binding reaction between albumin and bilirubin in the liquid phase. Thermodynamic equilibria and physical models are essential tools for designing adsorption columns aimed at detoxification treatments.

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