Esophageal cancer (EC) is a type of aggressive cancer without clinically relevant molecular subtypes, hindering the development of effective strategies for treatment. To define molecular subtypes of EC, we perform mass spectrometry-based proteomic and phosphoproteomics profiling of EC tumors and adjacent non-tumor tissues, revealing a catalog of proteins and phosphosites that are dysregulated in ECs. The EC cohort is stratified into two molecular subtypes—S1 and S2—based on proteomic analysis, with the S2 subtype characterized by the upregulation of spliceosomal and ribosomal proteins, and being more aggressive. Moreover, we identify a subtype signature composed of ELOA and SCAF4, and construct a subtype diagnostic and prognostic model. Potential drugs are predicted for treating patients of S2 subtype, and three candidate drugs are validated to inhibit EC. Taken together, our proteomic analysis define molecular subtypes of EC, thus providing a potential therapeutic outlook for improving disease outcomes in patients with EC.
Three-neutrino mixing in matter is studied through a set of evolution
equations which are based on a rephasing invariant parametrization. Making use
of the known properties of measured neutrino parameters, analytic, approximate,
solutions are obtained. Their accuracy is confirmed by comparison with
numerical integration of these equations. The results, when expressed in the
elements squared of the mixing matrix, exhibit striking patterns as the matter
density varies.Comment: Revised, 5 pages, 3 figures, references added
The evolution of the Cabibbo-Kobayashi-Maskawa matrix and the quark Yukawa couplings is performed for the one-loop renormalization group equations in the universal extra dimension model. It is found that the evolution of mixing angles and the CP violation measure J may rapidly vary in the presence of the Kaluza-Klein modes, and this variation becomes dramatic as the energy approaches the unification scale.
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