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CD is induced by ionizing radiation, however, the amount of CD detected at a certain point in time after radiation exposure is dependent on the initial frequency of CD induced and the death rate of cells with mtDNA containing CD. The novel mtDNA deletion found in this study, therefore, will be used to determine whether cells were exposed to ionizing radiation.

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Task allocation is a key issue of agent cooperation mechanism in Multi-Agent Systems. The important features of an agent system such as the latency of the network infrastructure, dynamic topology, and node heterogeneity impose new challenges on the task allocation in Multi-Agent environments. Based on the traditional parallel computing task allocation method and Ant Colony Optimization (ACO), a novel task allocation method named Collection Path Ant Colony Optimization (CPACO) is proposed to achieve global optimization and reduce processing time. The existing problems of ACO are analyzed; CPACO overcomes such problems by modifying the heuristic function and the update strategy in the Ant-Cycle Model and establishing a threedimensional path pheromone storage space. The experimental results show that CPACO consumed only 10.3% of the time taken by the Global Search Algorithm and exhibited better performance than the Forward Optimal Heuristic Algorithm. Based on the traditional parallel computing task allocation method and Ant Colony Optimization, Collection Path Ant Colony Optimization is proposed to achieve global optimization and reduce processing time. CPACO overcomes the existing problems of ACO by modifying the heuristic function and the update strategy in the Ant-Cycle Model and establishing a threedimensional path pheromone storage space.

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Artesunate (ARS) induced significant reactive oxygen species (ROS) generation in HepG2, HeLa, and A549 lines. However, ARS induced ROS-dependent apoptosis in HeLa and A549 cell lines but ROS-independent apoptosis in HepG2 cells. A total of 200 μM hydrogen peroxide (H 2 O 2) significantly induced cytotoxicity in HeLa cells, while H 2 O 2 up to 300 μM did not induce cytotoxicity in HepG2 cells, further demonstrating the strong resistance of HepG2 cells to ROS. HeLa cells had much higher basic total glutathione (T-GSH) level than HepG2 cells, while the ratio of basic reduced glutathione (GSH)/oxidized glutathione (GSSG) in HepG2 cells was nearly twice than that in HeLa and A549 cells. Inhibition of glutathione markedly enhanced H 2 O 2-or ARS-induced cytotoxicity in HeLa and A549 cell lines but modestly enhanced the cytotoxicity of H 2 O 2 and even did not affect the cytotoxicity of ARS in HepG2 cells. Moreover, addition of GSH remarkably prevented H 2 O 2-or ARS-induced cytotoxicity in HeLa and A549 cell lines, further indicating the involvement of GSH in scavenging ROS in the two cell lines. HepG2 cells exhibited higher catalase activity than HeLa cells, and inhibiting catalase activity by using 3-aminotriazole (3-AT, a specific inhibition of catalase) or catalase siRNA remarkably reduced the resistance of HepG2 cells to ROS, demonstrating the key roles of catalase for the strong resistance of HepG2 cells to ROS. Collectively, catalase activity instead of glutathione level dominates the resistance of cells to ROS.