Preparation, physicochemical property and in vitro antioxidant activity of zinc-Hohenbuehelia serotina polysaccharides complex

Wang, Lu; Li, Xiaoyü

doi:10.1016/j.ijbiomac.2018.10.118

Cited by 26 publications

(32 citation statements)

References 38 publications

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“…Mild or moderate zinc deficiency is considered to affect people worldwide, especially children and pregnant women. However, inorganic zinc supplementations such as zinc chloride are suspected to exhibit low bioavailability, poor zinc absorption, and toxicity in the gastrointestinal tract [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Pumpkin Skin Polysaccharide–Zn(II) Complex: Preparation, Characterization, and Suppression of Inflammation in Zebrafish

Dong

Zhang

et al. 2022

Foods

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In this study, pumpkin (Cucurbita moschata) skin polysaccharide–zinc(II) (PSP−Zn) complex was successfully prepared. The structure and physicochemical properties of PSP and PSP−Zn were analyzed. The anti-inflammatory activity of PSP and PSP−Zn was investigated in zebrafish larvae induced by copper sulphate. PSP and PSP−Zn consisted of rhamnose, arabinose, galactose, glucose, and galacturonic acid. The molecular weight (Mw) of PSP and PSP−Zn were 3.034 × 106 and 3.222 × 106 Da, respectively. Fourier transform infrared spectrum (FT-IR) and circular dichroism (CD) analysis results suggested that the chemical modification of zinc might occur through hydroxyl groups of PSP. The PSP−Zn complex had lamellar texture, smooth surface morphology, and larger particle size. X-ray Diffraction (XRD) analysis revealed that both PSP and PSP−Zn were semi-crystalline substances. PSP−Zn solution showed superior stability in a weak acid and alkaline environment, especially at pH = 6.0. Moreover, PSP and PSP−Zn showed a good inhibitory effect on inflammation cells in zebrafish. Real-time quantitative polymerase chain reaction (RT-PCR) result suggested that the anti-inflammatory mechanism of PSP and PSP−Zn were through downregulation of the expression of nitric oxide synthase 2b (nos2b), inducible nitric oxide synthase (iNOS), interleukin-6 (IL-6), and nuclear factor-kappa B2 (NF-κB2). The present study indicated that PSP−Zn is expected to be a safe and efficient novel zinc supplement with anti-inflammatory activity.

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Section: Introductionmentioning

confidence: 99%

Pumpkin Skin Polysaccharide–Zn(II) Complex: Preparation, Characterization, and Suppression of Inflammation in Zebrafish

Dong

Zhang

et al. 2022

Foods

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“…After IP3a was chelated with zinc, we found that IP3a-Zn had an amorphous state. The reason may be that polysaccharides are a heterogeneous class of carbohydrate polymers, composed of monosaccharide units and linked together by glycosidic bonds [23].…”

Section: Discussionmentioning

confidence: 99%

“…The reason may be that when the chelation time continues to increase, the stability of the reaction system is destroyed. The production rate of side reaction increased to a certain extent, which resulted in complexes dissociation and chelation reduction [23]. Therefore, the best chelation time of IP3a-Zn was 6 h.…”

Section: Effect Of Process Parameters On Chelation Ratementioning

confidence: 99%

Characterization, optimization of preparation process of an Inonotus obliquus polysaccharide-Zinc (II) complex and its antioxidant activities

Ding

Zhang

et al. 2021

Biotechnology & Biotechnological Equipment

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Zinc deficiency in human body has gradually become a major challenge to public health in modern society. In our previous work, a novel polysaccharide from Inonotus obliquus IP3a was successfully isolated and purified. The preparation process of IP3a-Zn was optimized by response surface methodology based on single factor experiments. Characterization and antioxidant activities of IP3a-Zn were investigated. The optimal preparation process of IP3a-Zn was obtained as follows: chelation time was 6.3 h, zinc (II) initial concentration was 4.6 mg/mL and mass ratio of IP3a to zinc sulfate heptahydrate was 4.8:1(mg/mg). The weight loss of IP3a-Zn was slightly smaller than that of IP3a within the heating temperature range. After chelation with zinc, IP3a-Zn had crystalline properties like IP3a. IP3a-Zn had stronger antioxidant activity than IP3a. The results indicated that chelation with zinc enhanced the antioxidant activity of IP3a. IP3a-Zn may serve as a good source of zinc as a supplement and could be used as an antioxidant for the food industries.

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“…Additionally, the Se-polysaccharide isolated from the mycelium of Ganoderma lucidum showed a tenfold higher inhibitory effect on the proliferation of human cancer cell lines when compared to the natural polysaccharide [388]. Further, in a study conducted by Wang et al, Se-polysaccharides from Hohenbuehelia serotina were isolated after the esterification of the polysaccharide with selenious acid [389]. Again, it was shown that the chemically modified compound had a greater antioxidant capacity than the natural polysaccharide [251].…”

Section: Fungal Se-polysaccharidesmentioning

confidence: 99%

Selenium-Containing Polysaccharides—Structural Diversity, Biosynthesis, Chemical Modifications and Biological Activity

2021

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Selenosugars are a group of sugar derivatives of great structural diversity (e.g., molar masses, selenium oxidation state, and selenium binding), obtained as a result of biosynthesis, chemical modification of natural compounds, or chemical synthesis. Seleno-monosaccharides and disaccharides are known to be non-toxic products of the natural metabolism of selenium compounds in mammals. In the case of the selenium-containing polysaccharides of natural origin, their formation is also postulated as a form of detoxification of excess selenium in microorganisms, mushroom, and plants. The valency of selenium in selenium-containing polysaccharides can be: 0 (encapsulated nano-selenium), IV (selenites of polysaccharides), or II (selenoglycosides or selenium built into the sugar ring to replace oxygen). The great interest in Se-polysaccharides results from the expected synergy between selenium and polysaccharides. Several plant- and mushroom-derived polysaccharides are potent macromolecules with antitumor, immunomodulatory, antioxidant, and other biological properties. Selenium, a trace element of fundamental importance to human health, has been shown to possess several analogous functions. The mechanism by which selenium exerts anticancer and immunomodulatory activity differs from that of polysaccharide fractions, but a similar pharmacological effect suggests a possible synergy of these two agents. Various functions of Se-polysaccharides have been explored, including antitumor, immune-enhancement, antioxidant, antidiabetic, anti-inflammatory, hepatoprotective, and neuroprotective activities. Due to being non-toxic or much less toxic than inorganic selenium compounds, Se-polysaccharides are potential dietary supplements that could be used, e.g., in chemoprevention.

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Preparation, physicochemical property and in vitro antioxidant activity of zinc-Hohenbuehelia serotina polysaccharides complex

Cited by 26 publications

References 38 publications

Pumpkin Skin Polysaccharide–Zn(II) Complex: Preparation, Characterization, and Suppression of Inflammation in Zebrafish

Pumpkin Skin Polysaccharide–Zn(II) Complex: Preparation, Characterization, and Suppression of Inflammation in Zebrafish

Characterization, optimization of preparation process of an Inonotus obliquus polysaccharide-Zinc (II) complex and its antioxidant activities

Selenium-Containing Polysaccharides—Structural Diversity, Biosynthesis, Chemical Modifications and Biological Activity

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