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Polaritons in polar biaxial crystals with extreme anisotropy offer a promising route to manipulate nanoscale light−matter interactions. The dynamic modulation of their dispersion is of great significance for future integrated nano-optics but remains challenging. Here, we report tunable topological transitions in biaxial crystals enabled by interface engineering. We theoretically demonstrate such tailored polaritons at the interface of heterostructures between graphene and α-phase molybdenum trioxide (α-MoO 3 ). The interlayer coupling can be modulated by both the stack of graphene and α-MoO 3 and the magnitude of the Fermi level in graphene enabling a dynamic topological transition. More interestingly, we found that the wavefront transition occurs at a constant Fermi level when the thickness of α-MoO 3 is tuned. Furthermore, we also experimentally verify the hybrid polaritons in the graphene/α-MoO 3 heterostructure with different thicknesses of α-MoO 3 . The interface engineering offers new insights into optical topological transitions, which may shed new light on programmable polaritonics, energy transfer, and neuromorphic photonics.

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Background. Cervical cancer is the second most common cancer among women worldwide. Extensive studies have shown that microRNAs (miRNA/miR) can regulate the formation, progression, and metastasis of cancer. The purpose of this study was to investigate the effect of miR-19-3p on the proliferation, invasion, and autophagy of cervical cancer cells and to explore the underlying mechanism. Methods. SiHa and HeLa cells were transfected with miR-19-3p mimic and inhibitor. miR-19-3p and PTEN expression were detected using real-time quantitative PCR and western blot, respectively. The binding between miR-19-3p and PTEN was predicted using Targetscan7.2 and verified by a dual-luciferase reporter gene assay. The effects of miR-19-3p on cell invasion and proliferation were evaluated by Transwell assays and MTT, respectively. The effect of miR-19-3p on autophagy was observed using fluorescence microscopy. Results. The expression of miR-19-3p in cervical cancer tissues and SiHa and HeLa cells was significantly upregulated, whereas the expression of PTEN was significantly downregulated. PTEN was one of the direct targets of miR-19-3p. The miR-19-3p mimic significantly reduced the apoptosis rate and autophagy and promoted cell proliferation and invasion of the SiHa and HeLa cells. Conclusion. In summary, miR-19b-3p can target PTEN to regulate the proliferation, invasion, and autophagy of cervical cancer cells. Our findings indicate the potential of miR-19-3p as a target for cervical cancer treatment in the future.

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Hydraulic fracturing (HF) technology is crucial to form connected fracture network within the low-permeability geothermal reservoir. However, the HF process and failure mechanism in this process are only partly understood. A series of true triaxial hydraulic fracturing tests on large-scale natural granite samples were conducted under different confining conditions, combining with acoustic emission monitoring to evaluate the initiation and propagation of hydraulic fractures. Results show that a main hydro-fracture was formed in three samples during the first fracturing process. Many AE events occurred during the first pump period. The proportion of tensile fractures during the hydraulic fracturing accounted for more than 85% of all fractures. The test results could provide a new understanding of the effect of HF under different stress conditions. And implied that field engineering should pay attention to the initial HF, which may determine the main fracture framework of the field at the first pump procedure.

For small urban landscape water algae bloom clean up the problems, designed a self-cleaning device bloom quickly. The device has: 1) for the urban landscape water algae bloom clean up, eliminate manual cleaning defects, breaking the city clean blind; 2) intelligent management control, real-time monitoring to meet the demand for manageable; 3) incorporated a variety of algae, view full clean water; 4) after processing cyanobacteria organic processing, and re-use waste resources.

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