Polaritons in polar biaxial crystals with extreme anisotropy offer a promising route to manipulate nanoscale light−matter interactions. The dynamic modulation of their dispersion is of great significance for future integrated nano-optics but remains challenging. Here, we report tunable topological transitions in biaxial crystals enabled by interface engineering. We theoretically demonstrate such tailored polaritons at the interface of heterostructures between graphene and α-phase molybdenum trioxide (α-MoO 3 ). The interlayer coupling can be modulated by both the stack of graphene and α-MoO 3 and the magnitude of the Fermi level in graphene enabling a dynamic topological transition. More interestingly, we found that the wavefront transition occurs at a constant Fermi level when the thickness of α-MoO 3 is tuned. Furthermore, we also experimentally verify the hybrid polaritons in the graphene/α-MoO 3 heterostructure with different thicknesses of α-MoO 3 . The interface engineering offers new insights into optical topological transitions, which may shed new light on programmable polaritonics, energy transfer, and neuromorphic photonics.
Recently, the fog computing concept has been introduced into vehicular ad-hoc networks (VANETs) to formulate fog-based VANETs. Since the communication channels between vehicles and fog nodes are open and insecure, it is necessary to construct an authenticated key agreement (AKA) scheme for securing the channels. The existing AKA schemes have two main deficiencies. One is that the computational and communication overhead are not low enough to satisfy the requirements of delay-sensitive applications. The other is that the multi-trustedauthority (multi-TA) model has not been considered. To solve the deficiencies, we propose a lightweight and conditional privacypreserving AKA scheme, where the main steps are designed with symmetric cryptography methods. The design can reduce the computational and communication overhead of the AKA process. Additionally, we consider the multi-TA model in the AKA process to solve the single-point-of-failure issue. By integrating Cuckoo filter into the multi-TA model, the secrecy of real identities of legal vehicles is guaranteed and the identity revocation function for illegal vehicles is supported in the AKA process. The security proof and analysis show that our proposed scheme satisfies the essential security and privacy requirements of VANETs. The performance analysis shows that our proposed scheme outperforms other related and represented schemes.
Background. Cervical cancer is the second most common cancer among women worldwide. Extensive studies have shown that microRNAs (miRNA/miR) can regulate the formation, progression, and metastasis of cancer. The purpose of this study was to investigate the effect of miR-19-3p on the proliferation, invasion, and autophagy of cervical cancer cells and to explore the underlying mechanism. Methods. SiHa and HeLa cells were transfected with miR-19-3p mimic and inhibitor. miR-19-3p and PTEN expression were detected using real-time quantitative PCR and western blot, respectively. The binding between miR-19-3p and PTEN was predicted using Targetscan7.2 and verified by a dual-luciferase reporter gene assay. The effects of miR-19-3p on cell invasion and proliferation were evaluated by Transwell assays and MTT, respectively. The effect of miR-19-3p on autophagy was observed using fluorescence microscopy. Results. The expression of miR-19-3p in cervical cancer tissues and SiHa and HeLa cells was significantly upregulated, whereas the expression of PTEN was significantly downregulated. PTEN was one of the direct targets of miR-19-3p. The miR-19-3p mimic significantly reduced the apoptosis rate and autophagy and promoted cell proliferation and invasion of the SiHa and HeLa cells. Conclusion. In summary, miR-19b-3p can target PTEN to regulate the proliferation, invasion, and autophagy of cervical cancer cells. Our findings indicate the potential of miR-19-3p as a target for cervical cancer treatment in the future.
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