In 1958 Francis Moore described the orthotopic liver transplantation technique in dogs. In 1963, Starzl et al. performed the first liver transplantation. In the first five liver transplantations no patient survived more than 23 days. In 1967, stimulated by Calne who used antilymphocytic serum, Starzl began a successful series of liver transplantation. Until 1977, 200 liver transplantations were performed in the world. In that period, technical problems were overcome. Roy Calne, in 1979, used the first time cyclosporine in two patients who had undergone liver transplantation. In 1989, Starzl et al. reported a series of 1,179 consecutives patients who underwent liver transplantation and reported a survival rate between one and five years of 73% and 64%, respectively. Finally, in 1990, Starzl et al. reported successful use of tacrolimus in patents undergoing liver transplantation and who had rejection despite receiving conventional immunosuppressive treatment. Liver Transplantation Program was initiated at Hospital Israelita Albert Einstein in 1990 and so far over 1,400 transplants have been done. In 2013, 102 deceased donors liver transplantations were performed. The main indications for transplantation were hepatocellular carcinoma (38%), hepatitis C virus (33.3%) and alcohol liver cirrhosis (19.6%). Of these, 36% of patients who underwent transplantation showed biological MELD score > 30. Patient and graft survival in the first year was, 82.4% and 74.8%, respectively. A major challenge in liver transplantation field is the insufficient number of donors compared with the growing demand of transplant candidates. Thus, we emphasize that appropriated donor/receptor selection, allocation and organ preservation topics should contribute to improve the number and outcomes in liver transplantation.

Primary graft dysfunction is a multifactorial syndrome with great impact on liver transplantation outcomes. This review article was based on studies published between January 1980 and June 2015 and retrieved from PubMed database using the following search terms: "primary graft dysfunction", "early allograft dysfunction", "primary non-function" and "liver transplantation". Graft dysfunction describes different grades of graft ischemia-reperfusion injury and can manifest as early allograft dysfunction or primary graft non-function, its most severe form. Donor-, surgery-and recipient-related factors have been associated with this syndrome. Primary graft dysfunction definition, diagnostic criteria and risk factors differ between studies.

Spanish has left-headed compounds which are not as productive as their left-headed counterparts in other languages. This presence or absence of productivity has been attributed to a binary parameter according to which N-N compounding, as opposed to nominal constructions in which the head noun takes a complement as in`the destruction of the city', would be the superset or marked option. Furthermore, the idiosyncratic nature of Spanish N-N compounding has been attributed to the make-up of Spanish Nouns. Specifically, it has been proposed that Spanish Nouns have a`word marker' which triggers L1 acquisition of these constructions. Based on the results of two picture tests intended to elicit actual command of N-N compounding strategies, as well as word order patterns and gender marking patterns, we argue that: 1) N-N compounding is not a marked construction; 2) adult L2 acquisition of Spanish N-N compounds is triggered by head directionality (a processing trigger) rather than by the`word marker' (a representational trigger) which is supposed to trigger L1 acquisition of these compounds.

Recent developments within the so-called Principles and Parameters model of acquisition argue for a clear-cut separation of Universal Grammar (UG) principles from parametric options and locate all parameters within functional categories (Borer, 1984;Lebeaux, 1988; Chomsky, 1991). This has led Tsimpli and Roussou (1991) to propose that adult L2 (second language) learners have access to UG principles but do not reset the parameters of the L2, which amounts to saying that null subjects in the adult Spanish L2 may or may not have the same status as native Spanish null subjects, depending on the speakers' L1 (first language) and the UG principles at stake. In the case of L1 acquisition, Rizzi (1994) and Hyams (1994) provide a competence account of null subjects in early child English which relate them to adult English Diary Drop and German-style topic-drop rather than to Spanish-style pro-drop. They specifically argue that these missing subjects are restricted to the first position of non-wh root clauses and that fixing the null subject parameter will consist of incorporating the ROOT=CP principle into this grammar. In this paper, we analyse the Spanish L2 oral spontaneous data produced by adult L1 speakers of pro-drop and topic-drop languages in an attempt to provide a competence account of null subjects in adult nonnative Spanish. Our data show that, unlike early English grammars, all the Spanish non-native grammars contain null subjects both in matrix and subordinate clauses, and that this is the case at the early and advanced stages. It also shows that many non-native pronominal subjects do not have the same value as native Spanish subjects and that subject pronouns are used for identification purposes. It is suggested that these data provide evidence for a model of L2 acquisition where adult non-native grammar construction resorts to a default licensing procedure which allows null pronouns provided they can be identified.

In recent research on primary (L1) and non-primary (L2) acquisition,special attention has been given to whether syntactic development is subject to a continuity condition. While it has been proposed that the continuity condition applies to both L1 and L2 syntactic growth,the changes that take place in developing grammars have sometimes been attributed to other cognitive systems. Specifically, it has been proposed that child grammars are ‘underspecified’ because they lack a pragmatic principle which determines the range of indices available for establishing verbal and nominal coreference. According to this proposal, a grammar which is underspecified for Number has null subjects and bare NPs only with non-inflected verb forms. Assuming that adults will not have a pragmatic deficit of the kind proposed for children, we have analysed data from child L1 Spanish and adult L2 Spanish. The results of our analysis show that: (1) in child L1 Spanish, the feature Person may encode Number so that when Person is distinctively implemented, root infinitives and bare NP subjects will cease to occur. However, the pervasive morphology of Spanish verbs conspires against the possibility of providing clear-cut evidence for underspecification in the case of child Spanish; (2) the different nature of L1 and L2 root infinitives may provide partial evidence for underspecification in the case of L1 Spanish; and (3) in the case of L2 learners, the distribution of null and overt subjects seems to be partially determined by their L1 rather than by underspecification.

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