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Objective-Although the epidemiology of typical endometrial carcinomas (grades 1-2 endometrioid or Type I) is well established, less is known regarding higher grade endometrioid or non-endometrioid carcinomas (Type II). Within a large Gynecologic Oncology Group trial (GOG-210), which included central pathology review, we investigated the etiologic heterogeneity of endometrial cancers by comparing risk factors for different histologic categories.Methods-Based on epidemiologic questionnaire data, risk factor associations, expressed as odds ratios (OR) with 95% confidence intervals (CI), were estimated comparing grade 3 endometrioid and Type II cancers (including histologic subtypes) to grades 1-2 endometrioid cancers. Results-Compared NIH Public Access

Objective To assess adherence to and acceptability of revised antiemetic prescribing guidelines implemented 2009 1 and evaluation of use of the patient-specifi c antiemetic record. Methods Case notes, prescription and administration charts were reviewed retrospectively for 20 patients receiving chemotherapy during April 2011. Prescribing of chemotherapy and antiemetics over the previous 12 months was recorded and adherence to guidelines assessed. Recently implemented patient sickness diary cards completed by patients/carers on each cycle of chemotherapy were evaluated. Prescribers' views and awareness of the guidelines were gathered from a specifically designed self-administered questionnaire. Outcomes from the study were presented at a multidisciplinary meeting where changes in practice were agreed. Results Of the 20 patients (11 oncology; 9 haematology), 13 were male and ranged from 6 months to 19 years old. Five patients had received chemotherapy for longer than 12 months. Prescribing adhered to the guidelines greater than 70% of the time in eight patients, between 30-70% of the time in 10 patients and less than 30% of the time in two patients. Nonadherence trends were: unclear documentation of patients group.bmj.com on March 17, 2015 -Published by

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