Nasal Cancer in U.S. Furniture Industry Counties

Brinton, LouiseA.; Stone, B. J.; Blot, W. J.; Fraumeni, JosephF.

doi:10.1016/s0140-6736(76)90691-7

Cited by 26 publications

(11 citation statements)

References 6 publications

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“…It seems clear, however, that agricultural exposure may not be unique in this regard, as a number of studies have implicated asbestos (Robertson et al, 1971), wood dust (Brinton et al, 1976;Decouffle et al, 1977), leather dust (Decouffle et al, 1977) and heavy metal exposure (Decouffle et al, 1977;Axelson et al, 1978) as factors with possible associations with myeloma.…”

Section: Discussionmentioning

confidence: 99%

Allergies and agricultural exposure as risk factors for multiple myeloma

Gallagher¹,

Spinelli²,

Elwood³

et al. 1983

Br J Cancer

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Summary In a case-control study of 84 multiple myeloma patients and 168 age-and sex-matched controls with tumours at other sites, reported prior allergies were associated with an elevated risk of myeloma (RR = 3.1, P<0.001). In addition, more myeloma patients than controls reported prior myxoedema (RR= 5.0 Incidence rates for multiple myeloma in British Columbia are 3.4 and 2.2 per 100,000 in males and females respectively (B.C. Ministry of Health, 1976). A recent study has indicated that the incidence has been increasing over the last 30 years (Velez et al., 1983). The highest reported incidence in the world is in U.S. black males (Waterhouse et al., 1976). Several occupational risks have been demonstrated, with Milham showing elevated mortality for myeloma among farmers, woodworkers, smeltermen and forgemen (Milham, 1976). Several studies have shown nuclear workers to be at high risk for myeloma (Dolphin, 1976;Lewis, 1963;Cuzick, 1981).Schafer and Miller in a study of 153 patients showed elevated risks of prior biliary disease and peptic ulcer in patients with IgA myeloma when compared to patients with all other myeloma types (Schafer & Miller 1979), and Allen found an elevated frequency among myeloma patients of individuals with group A blood (Allen, 1970). Familial occurrence of myeloma has been reported in spouses (Kyle et al., 1976) and in blood relatives (Maldonado & Kyle 1974 C) The

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Section: Discussionmentioning

confidence: 99%

Allergies and agricultural exposure as risk factors for multiple myeloma

Gallagher¹,

Spinelli²,

Elwood³

et al. 1983

Br J Cancer

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“…Various chemicals have been suggested as increasing the risk of myeloma, including asbestos, arsenic, cutting oils, heavy metals, petrochemicals, and materials associated with plastics and rubber manufacture, but none of these observations is secure (see Blattner, 1982, for a review). Increased risks in leather workers (Dorken & Vollmer, 1968;Decoufle et al, 1977) and woodworkers (Brinton et al, 1976;Milham, 1976) have also been reported. Failure of immune regulation is postulated to be important in myeloma, possibly resulting from the effects of chronic antigenic stimulation.…”

mentioning

confidence: 98%

Multiple myeloma – A case-control study

Cuzick¹,

Stavola²

1988

Br J Cancer

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A total of 399 patients with multiple myeloma and an equal number of match controls were interviewed about factors possibly related to the causes of their disease. Factors studied included occupation, chemical exposure, radiation exposure, prior diseases, immunizations, chronic infections and markers for defects in immune regulation. A strong risk associated with agriculture/food processing was observed (RR = 1.8, P = 0.002). The risk could not be restricted to those exposed to animals or meat products, or those exposed to pesticides. Significant excesses were also noted for reported exposures to chemicals and gases/fumes, but no specific agent or group of agents could be identified. Cases had fewer tonsillectomies above the age of 10 (P = 0.01). A large excess of shingles (herpes zoster) was observed in cases (P less than 0.001), but most of the excess cases occurred within 10 years of diagnosis, suggesting this was a preclinical manifestation of disease rather than a cause of it.

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“…9 In addition, an increased inci-(Specimen 3) was found to have undergone prior exdence of paranasal sinus carcinoma has been found ternal beam radiotherapy for the treatment of SCC. in nickel foundry workers, 10 furniture and leather Sample accrual was limited due to the rarity of this workers, [11][12][13] and in chronic snuff users. 14 However, tumor and due to uncertainties as to the exact patholseveral investigators have shown that the major risk ogies of many of the reviewed tumor samples.…”

Section: Methodsmentioning

confidence: 99%

p53 alteration and human papilloma virus infection in paranasal sinus cancer

Caruana

Zwiebel

Cocker

et al. 1997

Cancer

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These data suggest that p53 alterations and/or HPV infection are associated predominantly with IPs exhibiting evidence of dysplasia or IPs associated with SCC, but not in nondysplastic, benign IPs. In addition, an inverse correlation may exist between oncogenic HPV infection and p53 alterations in paranasal sinus tumors. The authors postulate that patients with IPs containing altered p53 may be at increased risk for SCC of the paranasal sinus.

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Nasal Cancer in U.S. Furniture Industry Counties

Cited by 26 publications

References 6 publications

Allergies and agricultural exposure as risk factors for multiple myeloma

Allergies and agricultural exposure as risk factors for multiple myeloma

Multiple myeloma – A case-control study

p53 alteration and human papilloma virus infection in paranasal sinus cancer

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