SummaryBackground-Metformin might reduce insulin requirement and improve glycaemia in patients with type 1 diabetes, but whether it has cardiovascular benefits is unknown. We aimed to investigate whether metformin treatment (added to titrated insulin therapy) reduced atherosclerosis, as measured by progression of common carotid artery intima-media thickness (cIMT), in adults with type 1 diabetes at increased risk for cardiovascular disease.

No abstract

alpha-Methyl-3,4-dihydroxy-DLphenylalanine has been found to be an effective inhibitor of aromatic amino acid decarboxylation in man. This was shown by decreased formation of serotonin, tryptamine, and tyramine from the precursor amino acids. Reduction of amine biosynthesis is associated with lowering of blood pressure in hypertensive patients and a transient sedative effect.

All of the equilibrium data on the ammonia synthesis reaction, which cover an extreme temperature range of from 325' to 952'C and an extreme pressure range (at some temperatures) of from 10 to 1000 atmospheres, are correlated with the compressibility and heat capacity data on the pure reacting gases by means of a rational and relatively simple equation for the mass action function E". In this equation the effect of temperature and of pressure on X"are separated, the relation for the temperature eRect being exact, but certain approximations being introduced for the sake of simplicity into the relation for the pressure eRect.All of the data on the ammonia synthesis equilibrium are represented within the experImental accuracy by the use of only two adjustable constants.

Vol. 58 coefficient calculations introduced by the use of inaccurate and inadequate thermal data. A subsequent communication will describe the application of these dilution measurements to some freezing point determinations recently made in this Laboratory.