The recent developments in time-domain diffuse optics that rely on physical concepts (e.g., time-gating and null distance) and advanced photonic components (e.g., vertical cavity source-emitting laser as light sources, single photon avalanche diode, and silicon photomultipliers as detectors, fast-gating circuits, and time-to-digital converters for acquisition) are focused. This study shows how these tools could lead on one hand to compact and wearable time-domain devices for point-of-care diagnostics down to the consumer level and on the other hand to powerful systems with exceptional depth penetration and sensitivity.

We consider a semiconductor microcavity driven by a coherent and stationary holding beam, in two distinct configurations. In the first, no carriers are injected in the multiple-quantum-well structure and the optical nonlinearity is governed by an excitonic resonance. The second corresponds to that of a vertical-cavity surfaceemitting laser kept slightly below threshold. We describe both configurations using a unified model that includes both field diffraction and carrier diffusion. We calculate numerically both the time evolution and the stationary profile of the solitonic solutions, using a generalization of the radial integration technique introduced by Firth and Scroggie ͓Phys. Rev. Lett. 76, 1623 ͑1996͔͒. We analyze the instability that forms spatial patterns and especially cavity spatial solitons. We predict the existence of these solitons in various parametric domains for both configurations. We demonstrate that these results are independent of the periodic boundary conditions used in the simulations. We show that, introducing a simple phase modulation in the holding beam, one can eliminate the motions of solitons that arise from noise and from amplitude gradients. The solitons are robust with respect to parametric variations, to carrier diffusion, and even to some amount of self-defocusing. This picture points to the possibility of realizing arrays of solitonic pixels using semiconductor microresonators.

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We propose a comprehensive statistical approach describing the penetration depth of light in random media. The presented theory exploits the concept of probability density function f(z|ρ, t) for the maximum depth reached by the photons that are eventually re-emitted from the surface of the medium at distance ρ and time t. Analytical formulas for f, for the mean maximum depth 〈zmax〉 and for the mean average depth reached by the detected photons at the surface of a diffusive slab are derived within the framework of the diffusion approximation to the radiative transfer equation, both in the time domain and the continuous wave domain. Validation of the theory by means of comparisons with Monte Carlo simulations is also presented. The results are of interest for many research fields such as biomedical optics, advanced microscopy and disordered photonics.

An experimental program has been carried out in order to investigate the mechanical behavior of porcine corneas. We report the results of inflation tests on the whole cornea and uniaxial tests on excised corneal strips, performed on 51 fresh porcine eyes. Uniaxial tests have been performed on specimens cut from previously inflated corneas. The cornea behavior is characterized by means of elastic stiffness, measured on both average pressure-apex displacement and average uniaxial stress-strain curves; and by means of transversal contraction coefficient, peak stress, and failure stress measured on uniaxial stress-strain curves. Uniaxial tests performed on excised strips allowed to measure the anisotropy in the corneal stiffness and to compare the stiffness of the cornea with the one of the sclera. Viscous properties of the cornea have been obtained through uniaxial relaxation curves on excised corneal strips. The relevant geometrical parameters have been measured and, with the aid of the elastic thin shell theory, a stress-strain curve has been derived from the average inflation test data and compared with similar data available in the literature. The experimental system has been developed in view of future applications to the mechanical testing of both porcine and human corneas.