Based on a systematic review and meta-analysis, patients with cirrhosis and PVT who receive anticoagulant therapy have increased recanalization and reduced progression of thrombosis, compared with patients who do not receive anticoagulants, with no excess of major and minor bleedings and less incidence of variceal bleeding.

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Objective-The inhibition of oxidative stress is among the most relevant pleiotropic effects of statins. The mechanism by which statins exert their antioxidant effect in vivo is still undefined. NADPH oxidase is among the most important sources of reactive oxygen species involved in atherosclerotic disease. Methods/Results-We developed an ELISA to evaluate serum levels of soluble-gp91 phox , the catalytic core of phagocyte NADPH oxidase. In a cross-sectional study performed in 30 hypercholesterolemic patients and in 20 controls, serum soluble-gp91 phox and urinary isoprostane, a marker of oxidative stress, were measured. The 2 variables were also measured in hypercholesterolemic patients, randomized to diet (nϭ15), or diet plus atorvastatin (10 mg daily, nϭ15) and followed for 30 days. Compared to controls, hypercholesterolemic patients had higher and significantly correlated (Rϭ0.71; PϽ0.001) serum soluble-gp91 phox (PϽ0.001) and urinary isoprostanes (PϽ0.001). After follow-up, the statin-allocated group showed a significant reduction of soluble-gp91 phox (Ϫ33%, PϽ0.01), that paralleled that of isoprostanes (Ϫ37%, PϽ0.01) and cholesterol (Ϫ25%, PϽ0.01). The diet-allocated group showed only a weak reduction of cholesterol. Key Words: gp91 phox Ⅲ oxidative stress Ⅲ hypercholesterolemia Ⅲ NADPH oxidase Ⅲ statins P rimary and secondary prevention trials with statins clearly demonstrated that this drug category is able to reduce cardiovascular events. 1,2 Even if the principal mechanism of action of statins is to lower cholesterol, other effects, the so-called pleiotropic effects, have been considered as adjunctive properties potentially accounting for the antiatherosclerotic effect of statins. 3 Inhibition of oxidative stress may be considered an intriguing pleiotropic effect in view of the fact that oxidative stress is thought to be a key event in the initiation and progression of atherosclerotic disease. 4 Reduction of several markers of oxidative stress including isoprostanes, 8-hydroxydeoxyguanosine (8-OHdG), and nitrotyrosine have been observed after statin treatment but the underlying mechanism is still unclear. [5][6][7][8][9] In a pilot study performed in patients with chronic granulomatous disease (X-CGD), a very rare life-threatening disease secondary to hereditary deficiency of gp91 phox (the catalytic subunit of phagocyte NADPH oxidase), we found a significant reduction of urinary isoprostanes. 10 Also, in children with hypercholesterolemia, we observed a significant correlation between platelet gp91 phox expression and urinary isoprostanes. 11 These previous observations suggest a role for the phagocyte NADPH oxidase, one of the most important cellular producers of superoxide anion (O 2 . ), 12 in the formation of this marker of oxidative stress. Because previous studies provided in vitro evidence that statins inhibit the expression and activation of NADPH oxidase, 6,13 we sought to analyze whether this occurs in vivo and ultimately contributes to the reduction of oxidative stress. Thus, we developed ...

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The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a serious public health emergency in Eastern Countries as well as in Europe and United States, causing the new pandemic with increasingly numbers of infected people and deaths. The clinical presentation of SARS-CoV-2-related disease (COVID-19) is highly variable, ranging from asymptomatic/pauci-symptomatic patients to acute respiratory distress syndrome (ARDS) and sepsis, with patients needing admission to intensive care unit (ICU) and mechanical ventilation. 1 Thus, SARS-CoV-2 infection

This study shows that in PAD patients, oxidative stress is implicated in determining reduced FMD.

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These findings indicate that oleuropein improves postprandial glycaemic profile via hampering Nox2-derived oxidative stress.