Met opmerkingen [TDV1]: Author guidelines for "Physical Therapy" Journal Max 4000 words Max 6 tables/figures Max 75 refs (AMA reference style) Title max 150 characters 12-point font, double spacing  pages AND lines numbered. Submit both a masked copy and an unmasked copy. In the masked version, please remove author names and any affiliations within the article. https://academic.oup.com/ptj/pages/Author_Guidelines#Wh at is Your Article Type?References. References should be listed in the order of appearance in the manuscript, by numerical superscripts that appear consecutively in the text. Please follow AMA reference style. If you use End Notes, please use version 6.0 or higher. Tables. Tables should be formatted in Word, numbered consecutively, and placed together at the end of the manuscript. In tables that describe characteristics of 2 or more groups:• Report averages with standard deviations when data are normally distributed.• Report median (minimum, maximum) or median (25th, 75th percentile [interquartile range, or IQR]) when data are not normally distributed.

Two years after breast cancer surgery, physical activity levels are still significantly lower compared to pre-operative values. Based on this limited recovery, it seems important to monitor physical activity levels in breast cancer patients and advice these patients to stay active after surgery and return to pre-operative activity levels in the long term as well. This study indicates the importance of long term monitoring and subsequently coaching of physical activity after breast cancer surgery.

A single BTX-A infiltration in combination with an individual physical therapy program significantly decreased pain intensity at the upper limb in breast cancer survivors up to 6 months. However, the effect size was not clinically relevant, and no other beneficial effects were found.

Pain during, and especially after, cancer remains underestimated and undertreated. Moreover, both patients and health care providers are not aware of potential benefits of rehabilitation strategies for the management of pain during and following cancer treatment. In this paper, we firstly provided a state-of-the-art overview of the best evidence rehabilitation modalities for patients having (persistent) pain during and following cancer treatment, including educational interventions, specific exercise therapies, manual therapies, general exercise therapies and mind-body exercise therapies. Secondly, the findings were summarized from a clinical perspective and discussed from a scientific perspective. In conclusion, best evidence suggests that general exercise therapy has small pain-relieving effects. Supporting evidence for mind-body exercise therapy is available only in breast cancer patients. At this moment, there is a lack of high-quality evidence to support the use of specific exercises and manual therapy at the affected region for pain relief during and after cancer treatment. No clinically relevant results were found in favor of educational interventions restricted to a biomedical approach of pain. To increase available evidence these rehabilitation modalities should be applied according to, and within, a multidisciplinary biopsychosocial pain management approach. Larger, well-designed clinical trials tailored to the origin of pain and with proper evaluation of pain-related functioning and the patient’s pain experience are needed.

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This study was funded by the MSD OncoAward. The funding source had no role in study design, data collection, data analysis, data interpretation, or writing of the report. We had no support from any organisation for the submitted work; no financial relationships with any organisation that might had an interest in the submitted work in the previous three years; no other relationships or activities that could appear to have influenced the submitted work. We had full control of all primary data and we agree to allow the journal to review the data if requested. The authors have no further conflicts of interest.

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