Physical activity levels after treatment for breast cancer: Two-year follow-up

Groef, An De; Geraerts, Inge; Demeyer, Heleen; Gucht, Elien Van der; Dams, Lore; Kinkelder, Carlijn de; Althuis, Sanne Dukers-van; Kampen, Marijke Van; Devoogdt, Nele

doi:10.1016/j.breast.2018.04.009

Cited by 75 publications

(47 citation statements)

References 29 publications

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“…60--- 62 The results of this review showed that many patients only engaged in light-intensity activity following gynaecological cancer diagnosis and treatment. These results are consistent with previous studies in mixed cancer, 63 breast cancer 64,65 and colorectal cancer cohorts, 66 showing that cancer survivors significantly reduce their total, vigorous and moderate intensity PA 6 months and 1 year after diagnosis or treatment. The present review adds further evidence to demonstrate persistent low PA levels among patients following gynaecological cancer diagnosis and suggests that exercise recommendations for other cancer cohorts may also be applicable to this population.…”

Section: Discussionsupporting

confidence: 92%

The impact of gynaecological cancer treatment on physical activity levels: a systematic review of observational studies

Lin

Edbrooke

Granger

et al. 2019

Brazilian Journal of Physical Therapy

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Background: The natural history of physical activity levels during and following gynaecological cancer treatment is not well understood. This is required in order to establish the time at which physical activity levels are lowest in order to target cancer rehabilitation or exercise interventions in gynaecological cancer population accordingly. Objectives: To conduct a systematic review to evaluate the impact of gynaecological cancer treatments on physical activity levels and to summarise the pattern of changes in physical activity levels over time among patients with gynaecological cancer.

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Section: Discussionsupporting

confidence: 92%

The impact of gynaecological cancer treatment on physical activity levels: a systematic review of observational studies

Lin

Edbrooke

Granger

et al. 2019

Brazilian Journal of Physical Therapy

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“…Despite recommendations of staying physically active after a cancer diagnosis, most patients with cancer and cancer survivors decrease PA level and struggle to meet PA recommendations [ 36 , 37 ]. In a longitudinal study conducted by De Groef et al [ 38 ], self-reported levels of activity were investigated among 267 patients with breast cancer before surgery and at several following time points. After 2 years, all activity levels (total, sports, occupational and household) were statistically significantly lower compared to preoperative levels [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…In a longitudinal study conducted by De Groef et al [ 38 ], self-reported levels of activity were investigated among 267 patients with breast cancer before surgery and at several following time points. After 2 years, all activity levels (total, sports, occupational and household) were statistically significantly lower compared to preoperative levels [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

The effect of exercise-based interventions on health-related quality of life and physical function in older patients with cancer receiving medical antineoplastic treatments: a systematic review

Mikkelsen

Juhl

Lund

et al. 2020

Eur Rev Aging Phys Act

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Older patients with cancer are underrepresented in trials investigating the effect of exercise therapy. The aim of this systematic review was to investigate the effect of exercise therapy during medical antineoplastic treatment in older patients (≥ 65 years) with cancer. A systematic review following the Cochrane guidelines was performed. Randomized controlled trials were identified through a systematic literature search in MEDLINE, EMBASE, CENTRAL, and CINAHL up to December 2019. Study selection was performed independently by two reviewers. Four randomized controlled trials published between 2014 and 2019 were included comprising a total of 412 participants. Most participants were diagnosed with breast, prostate or colorectal cancer. The studies were characterized by large differences in design, interventions and outcomes, which prevented meta-analyses. The interventions ranged from 4 weeks to 12 months and involved both supervised and unsupervised exercise programs. Some evidence of beneficial effects from the interventions were documented on physical function, muscle strength, physical activity and cognitive function. No evidence of effects was found for health-related quality of life, aerobic capacity, body composition, cancer-related symptoms and side effects, or for any clinical outcomes. No adverse events were reported. Exercise therapy seems to be safe and feasible in older patients with cancer. However, due to a limited number of studies, small sample sizes and heterogeneity across study design, the effects of exercise in older patients with cancer receiving medical antineoplastic treatment are inconclusive.

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“…Breast cancer (BC) is one of the top three cancers across the world with different treatment modes depending on the different subtypes (4). However, the current applicable treatment for BC exerts a considerable large and prolonged impact on the activity levels of BC survivors (20). This study aims to explore the potential regulatory role of hsa_circRPPH1_015 in the development of BC.…”

Section: Discussionmentioning

confidence: 99%

A Novel Circular RNA hsa_circRPPH1_015 Exerts an Oncogenic Role in Breast Cancer by Impairing miRNA-326-Mediated ELK1 Inhibition

Zhao

et al. 2020

Front. Oncol.

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Background: Breast cancer (BC) represents a heterogeneous disease with distinct subtypes and high tumor metastatic potentials. Recent researchers identify the implication of circular RNAs (circRNAs) in the initiation of BC. Herein, we uncover a novel circRNA hsa_circRPPH1_015 as a tumor promoter in BC. Methods: A total of 86 paired cancerous and non-cancerous tissues were surgically resected and collected from BC patients. Cell proliferation, colony formation, and cell invasion were examined by Edu staining, clone formation assays, propidium iodide (PI)-labeled flow cytometry, and Transwell invasion assays. PCNA, Ki67, MMP-2, MMP-9, Cyclin D1, and CDK4 expression was assayed using Western blot analysis. RNA pull-down, dual-luciferase reporter gene assay, and RNA binding protein immunoprecipitation (RIP) assay were performed to investigate the relationships among hsa_circRPPH1_015, microRNA-326 (miR-326), and ELK1. The tumor growth of human BC MCF-7 cells in vivo was evaluated in nude mice by subcutaneous xenografts of MCF-7 cells. Results: hsa_circRPPH1_015 expression was upregulated in BC tissues. Knockdown of hsa_circRPPH1_015 restrained the aggressive behavior of MCF-7. hsa_circRPPH1_015 could bind to miRNA-326 that negatively regulates ELK1. Elevation of miRNA-326 expression resulted in inhibition of cell proliferation, colony formation, and cell invasion of MCF-7. Disturbance of miRNA-326 or overexpression of ELK1 restored the proliferation and aggressiveness in hsa_circRPPH1_015-depleted MCF-7 cells. Tumor growth of MCF-7 cells in vivo was reduced in nude mice lack of endogenous hsa_circRPPH1_015 expression. Conclusion: Overall, the present study demonstrates that hsa_circRPPH1_015 was an oncogene and unfavorable prognostic factor in BC, providing an exquisite therapeutic target for BC.

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Physical activity levels after treatment for breast cancer: Two-year follow-up

Cited by 75 publications

References 29 publications

The impact of gynaecological cancer treatment on physical activity levels: a systematic review of observational studies

The impact of gynaecological cancer treatment on physical activity levels: a systematic review of observational studies

The effect of exercise-based interventions on health-related quality of life and physical function in older patients with cancer receiving medical antineoplastic treatments: a systematic review

A Novel Circular RNA hsa_circRPPH1_015 Exerts an Oncogenic Role in Breast Cancer by Impairing miRNA-326-Mediated ELK1 Inhibition

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